oxidative deamination


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Related to oxidative deamination: urea cycle

ox·i·da·tive de·am·i·na·tion

deamination by enzymes that uses flavin or pyridine nucleotides (such as FAD or NAD+).
Farlex Partner Medical Dictionary © Farlex 2012

oxidative deamination

a deamination that also involves an oxidation, for example, an alpha amino acid to an alpha keto acid.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Other minor phase I reactions included isopropyl hydroxylation (F3, F5), A-depentylation (F4), oxidative deamination of the carboxamide group (F10-F12), and isopropyl dehydrogenation (F11, F12).
F10, F11, and F12 were minor third and fourth generation metabolites combining oxidative defluorination and subsequent carboxylation and oxidative deamination (F10), oxidative defluorination, oxidative deamination, and isopropyl dehydrogenation (F11) and oxidative defluorination and subsequent carboxylation, oxidative deamination, and isopropyl dehydrogenation (F12).
Monoamine oxidases (MAOs) are flavoproteins which catalyze the oxidative deamination of a variety of neurotransmitters, such as noradrenaline, dopamine, and serotonin, as well as different exogenous and endogenous amines (i.e., tyramine, benzylamine, etc.) to their corresponding aldehydes.
(ii) synthesis of [H.sub.2][O.sub.2] by monoamine oxidase (MAO), during oxidative deamination of catecholamines (outer membrane of mitochondria),
Also MAO, flavin enzymes located in the outer membrane of mitochondria, are responsible for oxidative deamination of catecholamines, resulting in synthesis of [H.sub.2][O.sub.2] leading in turn to highly reactive HO- [93,99].
3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an endogenous catecholaldehyde produced by oxidative deamination of dopamine.
Oxidative deamination of MAO substrates that produces hydrogen peroxide and the corresponding aldehyde is selectively prevented by propargylamines (clorgyline and deprenyl) [5].
VMA may also be produced by the oxidative deamination of normetanephrine and metanephrine or by O-methylation of dihydroxymandelic acid, a minor metabolite of norepinephrine (2,3).

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