oxidative burst

oxidative burst

the production of reactive oxygen species (ROS) by certain cells, particularly MACROPHAGES and NEUTROPHILS, following challenge by a PATHOGEN. The ROS are generated irrespective of the type of pathogen, be it bacterial, fungal or viral. ROS generation leads to the killing of pathogens engulfed by PHAGOCYTOSIS. There is rapid activation of LEUKOCYTE NADPH oxidase, which catalyses formation of the superoxide ion (.O2 -). This then forms H2 O2, which can kill engulfed bacteria, unless they are protected by CATALASE.

Neutrophils contain the enzyme myeloperoxidase, which converts H2 O2 to hypochlorous acid (HOCl) in the presence of chloride ions. This dissociates to the hypochlorite ion (OCl-), which is a powerful oxidant and antimicrobial agent, that can damage cell membranes, genetic material and cause cell death.

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Collagen synthesis, phagocyte oxidative burst activity, the ability of B-cells and T-cells to work properlyare all due to Vitamin C.
Increasing tissue oxygen tension to 30 mm Hg or greater increases the macrophages' ability to have an oxidative burst needed to kill bacteria.
Activity of compounds was investigated by looking their influence on oxidative burst activity of zymosan stimulated whole blood phagocytes by using a luminol enhanced chemiluminescence technique.
Antioxidant enzymes involves in scavenging reactive oxygen species in the cellular system and safe guard the cells from oxidative burst.
The aim of the present study was to evaluate the effect of this therapy on absolute neutrophil counts (ANC), blood neutrophilic function (phagocytosis, oxidative burst activity), serum naturally occurring antibodies (NAbs), procalcitonin (PCT) in infected animals.
Laboratory evaluation for neutrophil's oxidative burst was performed and diagnosis of chronic granulomatous disease (CGD) was confirmed by both negative Nitroblue tetrazolium test (NBT) and lack of dihydrorhodamine (DHR) fluorescence following neutrophil stimulation against phorbol myristate acetate (PMA).
In contrast, CD137, a costimulatory immune checkpoint molecule, could reduce typical macrophage characteristics such as phagocytosis, oxidative burst, and CD14 expression, which could induce the differentiation of monocytes to dendritic cells (DC) and DC maturation and reduce ROS generation [39].
To evaluate plant defense response, oxidative burst and phenol-oxidizing enzymes were assayed.
non-cellular mechanisms, and 2) the excessive formation of ROS by the oxidative burst of macrophages and neutrophils activated during particle phagocytosis and persistent inflammation [6].
Staph has the ability to defeat the body's immune system with catalase, the enzyme that breaks down peroxide, and nitric oxide, the usual killer of bacteria with the oxidative burst from white blood cells.
We measured degranulation and oxidative burst, 2 fundamental components of phagocytosis, and we predicted that the functional effectiveness of these innate immune responses would correspond to the species' relative resistance to WNV.
Mechanisms of action include direct antibacterial activity, indirect antibacterial activity such as inhibition of host epithelia and group A streptococci, improved phagocytosis, improved oxidative burst and intracellular killing by human peripheral blood phagocytes, release of tumour necrosis factor and nitric oxides and a number of other activities.

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