oxiconazole


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oxiconazole

 [ok″sĭ-kon´ah-zōl]
a topical antifungal agent used as the nitrate salt in treatment of athlete's foot and ringworm.

oxiconazole

(ox-i-kon-a-zole) ,

Oxistat

(trade name)

Classification

Therapeutic: antifungals
Pregnancy Category: B

Indications

Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor (cream only).

Action

Affects the synthesis of the fungal cell wall.

Therapeutic effects

Decrease in symptoms of fungal infection.

Pharmacokinetics

Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Systemic metabolism and excretion not known following local application.
Half-life: Not applicable.

Time/action profile

ROUTEONSETPEAKDURATION
Topunknownunknownunknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / / Lactation: Safety not established.

Adverse Reactions/Side Effects

Local

  • burning
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging

Interactions

Drug-Drug interaction

Not known.

Route/Dosage

Topical (Adults and Children) Apply cream or lotion once or twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Apply cream once daily in patients with tinea versicolor. Patients with tinea corporis, tinea cruris, or tinea versicolor should be treated for 2 wk. Patients with tinea pedis should be treated for 4 wk.

Availability

Cream: 1%
Lotion: 1%

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)

Implementation

  • Consult physician or other health care professional for proper cleansing technique before applying medication.
    • Lotion is usually preferred in intertriginous areas; if cream is used, apply sparingly to avoid maceration.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by physician or other health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream or lotion can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection. Early relief of symptoms may be seen in 2–3 days. For tinea cruris, tinea corporis, and tinea versicolor, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.
References in periodicals archive ?
affect nails or oxiconazole mentagrophytes, hair Epidermophyton spp.) Bacterial intertrigo Staphylococcus Well-defined Topical (27) aureus erythematous mupirocin macule or plaque with maceration Group A Well-defined Topical (27, 31) beta-hemolytic erythematous mupirocin streptococci macule or plaque or oral without satellite penicillin lesions; associated with foul odor and exudate Erythasma, Well-defined brown Oral (33, 34) Corynebacterium to reddish plaque; erythromycin minutissimum occasional central or topical clearing of lesion; erythromycin diagnosis by the or clindamycin presence of coral-red fluorescence on Wood lamp examination Table 2 | Dermatologic conditions localized to the axilla: lesion type, color, and distinguishing characteristics.
[5] Imidazole group of antifungals are commonly used in vaginal candidiasis which includes clotrimazole, fluconazole, isoconazole, oxiconazole, omoconazole and tioconazole.
azole antifungals in this pharmacologic class: clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Kuric), miconazole (Micatin), oxiconazole (Oxistat), sertaconazole (Ertaczo), and sulconazole (Exelderm).
They can be treated with topical drugs, including clotrimazole, econazole, oxiconazole, ciclopirox, terbinafme, and ketoconazole.
I treat the areas between the toes with oxiconazole nitrate cream, I wash vigorously to remove loose skin cells, and I even use separate foot towels to dry off.
They can be treated with a wide variety of topical drugs, among them clotrimazole, econazole, oxiconazole, ciclopirox, terbinafine, and ketoconazole.
Options include econazole, ketoconazole, oxiconazole, and sulconazole.
The fungicidal allylamines (naftifine and terbinafine) and butenafine (allylamine derivative) are a more costly group of topical tinea treatments, yet they are more convenient as they allow for a shorter duration of treatment compared with fungistatic azoles (clotrimazole, econazole, ketoconazole, oxiconazole, miconazole, and sulconazole).
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
Also, oxiconazole is available in a lotion, which is helpful in tinea pedis cases.