TX, a member of the oxicams class, is widely used to relieve swelling, inflammation, stiffness, and pain associated with osteoarthritis, rheumatoid arthritis, arthrosis, ankylosing spondylitis, arthritic diseases such as tendinitis, bursitis, shoulder or hip periarthritis (shoulder-hand syndrome), sprains and injuries, and acute gout.
Stability-indicating chromatographic methods for the determination of some oxicams. J AOAC Int.
Meloxicam (COX-2 inhibitor) and piroxicam (COX-1 inhibitor) for oxyradical production in rat gastric mucosa, and observed that both the oxicams showed gastric mucosal damage at similar extent .
Sarkar, Photophysical Studies of Oxicam Group of NSAIDs: Piroxicam, Meloxicam and Tenoxicam, Spectrochim Acta.
There were 1 patient (3.8%) each attributed to coxibs, aspirin and oxicams
and 2 patients (7.6%) due to etodolac.
Tenoxicam belongs to the class of NSAIDs known as oxicams
, which exert potent anti-inflammatory and analgesic actions by inhibiting prostaglandin synthesis.
. No data are available on the effects of oxicams
on male fertility.
Krzek, "A review of analytical techniques for determination of oxicams
, nimesulide and nabumetone," Talanta, vol.
NSAIDs commercial can be grouped, based on a chemical point of view, into three main classes: (1) carboxylic acids, (2) phenazones (pyrazolones, oxicams
), and (3) nonacidic compounds.
Radulovic (1989) Oxicams
: metabolic disposition in man and animals.
Lornoxicam is a new compound combining the potency of the "oxicams
" with reduced risk of side effects.
Lornoxicam (chlortenoxicam), a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam
class with analgesic, anti-inflammatory and antipyretic properties, is distinguished from established oxicams
by a relatively short elimination half-life (3 to 5 hours), which may be advantageous from a tolerability standpoint.