Data from a 24-month interim analysis of the Company's ongoing open-label phase 2 extension study in PH-patients on a stable dialysis regimen, has previously shown a consistent and long-lasting reduction of plasma oxalate
together with a clinical improvement in cardiac function.
In animal models of PH, DCR-PHXC selectively silences lactate dehydrogenase A enzyme, or LDHA, in the liver, blocking the excess production of oxalate
, a hallmark of the disease.
The stones were analyzed using a kit for semi-quantitative colorimetric determination of carbonate, calcium, magnesium, ammonium, oxalate
, phosphate, uric acid and cysteine; manufactured by LTA s.r.l.
###Poly(bisphenol A oxalate
)###Al-Hamidi et al., (2008) 
High levels of calcium in the blood can predispose a cat to form calcium oxalate
Isolation and identification of oxalate
oxidase producing bacteria
Soil properties which are likely to be significant in this regard are pH, sorption sites for both [Ca.sup.2+] and oxalate
, compounds which may oxidise oxalate
On the other hand, these drugs may induce the formation of calculi through its metabolic action by interfering with calcium oxalate
or purine metabolisms .
Worcester et al., "Contrasting histopathology and crystal deposits in kidneys of idiopathic stone formers who produce hydroxy apatite, brushite, or calcium oxalate
stones," Anatomical Record, vol.
Using a Leica DM 1000 light microscope, examination of hematoxylin and eosin stained histology slides revealed the abdominal air sac wall was diffusely thickened by an exudate of fibrin, heterophils, and fewer macrophages with entrapped oxalate
crystals (Figure 3).
Figure 2 Shows the FTIR spectra of oxalate
precursors synthesized by coprecipitation using A.