OVGP1

(redirected from oviduct-specific glycoprotein)

OVGP1

A gene on chromosome 1p13 that encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites. OVGP1 is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Gene expression occurs during late follicular development through early cleavage-stage embryonic development, and may be oestrogen dependent. The protein is secreted by non-ciliated oviductal epithelial cells, associates with ovulated oocytes, blastomeres and spermatozoan acrosomal regions, and is thought to play a role in fertilisation and/or early embryonic development.
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References in periodicals archive ?
Oviduct-specific glycoprotein modulates sperm-zona binding and improves efficiency of porcine fertilization in vitro.
Oviduct-specific glycoprotein and heparin modulate sperm-zona pellucida interaction during fertilization and contribute to the control of polyspermy.
Using this approach, polymorphisms in some defined genes such as the estrogen receptor (Li et al., 2004), follicle-stimulating hormone-[beta] (Li et al., 2002) and Oviduct-specific Glycoprotein 1 (Niu et al., 2006) have all been reported to be associated with litter size in swine.
Mucins belong to the family of glycoproteins identified as the oviduct-specific glycoproteins (OGPs) [2].
Association of oviduct-specific glycoproteins with human and baboon (Papio anubis) ovarian oocytes and enhancement of human sperm binding to human hemizonae following in vitro incubation.