OVGP1

(redirected from oviduct-specific glycoprotein)

OVGP1

A gene on chromosome 1p13 that encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites. OVGP1 is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Gene expression occurs during late follicular development through early cleavage-stage embryonic development, and may be oestrogen dependent. The protein is secreted by non-ciliated oviductal epithelial cells, associates with ovulated oocytes, blastomeres and spermatozoan acrosomal regions, and is thought to play a role in fertilisation and/or early embryonic development.
References in periodicals archive ?
In porcine, the oviduct-specific glycoprotein (OVGP1) increases the rate of monospermy in in vitro fertilized oocytes through induction of zona hardening and interaction with spermatozoa (42).
Oviduct-specific glycoprotein modulates sperm-zona binding and improves efficiency of porcine fertilization in vitro.
Oviduct-specific glycoprotein and heparin modulate sperm-zona pellucida interaction during fertilization and contribute to the control of polyspermy.
Oviductal epithelium of the baboon: hormonal control and the immuno-gold localization of oviduct-specific glycoproteins.
2002) and Oviduct-specific Glycoprotein 1 (Niu et al.
Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size and Weight of Ovaries in Pigs.