(3) Genes (2) Ratio (%) 1 6 6 0.61 985 2 9 12 1.18 1,021 3 8 8 0.58 1,372 4 9 10 1.17 855 5 7 7 0.53 1,323 6 6 7 1.01 692 7 14 15 1.07 1,396 8 5 5 0.60 829 9 6 6 1.00 602 10 6 7 0.65 1,074 11 9 9 0.86 1,047 12 4 4 0.97 414 13 7 7 0.82 850 14 1 1 0.18 571 15 4 4 0.38 1,050 16 8 8 1.13 710 17 11 12 1.80 665 18 12 16 1.29 1,236 19 12 13 0.97 1,347 20 0 0 0.00 384 21 9 9 1.23 731 22 7 7 1.15 608 23 3 4 0.51 785 24 7 7 2.02 347 25 23 35 4.57 766 26 5 5 1.14 437 27 1 1 0.36 274 28 4 4 1.13 355 29 2 3 0.43 705 X 6 7 0.62 1,128 (1) The number of variations
overlapping genes. (2) The total number of genes overlapping variations.
For comparisons of gene expression to human tissue-specific gene expression from GTEx (GTEx Consortium, 2015), normalized counts for each cardiomyocyte donor were combined with median tissue counts downloaded from the GTEx portal and
overlapping genes were kept (n = 2640).
Overlapping genes are an integral component of the genome.
We defined the common targets (
overlapping genes) as predicted targets for both the reference and derived alleles of a SNP.
By comparing the data in several databases, we found that two
overlapping genes and their corresponding transcripts have been given the name BCYRN1 (BC200): a gene 13,458 nt in length (chr2:47,331,060-47,344,517, GRCh38, Gencode Transcript ENST00000418539.1, and Gencode Gene ENSG00000236824.1) and a gene 200nt in length (chr2:47,335,315-47,335,514, GRCh38, Gencode Transcript ENST00000418539.2, and Gencode Gene ENSG00000236824); the two genes are in the same orientation.
Genes that exist in multiple pathways were considered as
overlapping genes. These genes are thought to play multiple roles in hypothesis testing, where the weight coefficients were overestimated.
This observation indicates that these 27
overlapping genes may be strong candidates for zebrafish Nrf2 targets (Figure 3(a), indicated genes; Table S3, gray highlighted).
For the genes positively and negatively correlated with KRAS, NRAS, and HRAS expression, we analyzed the number of
overlapping genes and enriched pathways.
where TP indicates the number of
overlapping genes found in our method and annotated genes associated with cancers in CGC.
SNPs detection in DHPS-WDR83
overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH.
(2013a) and searched for overlap between this list and the list of differentially expressed, down-regulated, up-regulated, and
overlapping genes defined in this study.