Essentially it's an overgrowth syndrome
and it means everything grows very, very quickly.
Small bowel bacterial overgrowth syndrome
may be an underappreciated cause of malnutrition, especially in the elderly.
We previously have shown that fructose malabsorption is a promoting factor for small intestinal bacterial overgrowth syndrome
and is associated with higher serum neopterin concentrations (19), an indicator of immune activation.
Bacterial populations contaminating the upper gut in patients with small intestinal bacterial overgrowth syndrome
The possibility of bacterial overgrowth was considered, and routine qualitative urinary organic acid analysis (gas chromatography-mass spectrometry) (4) revealed increased excretion of lactate, 3-hydroxypropionate, phenyllactate, and 4-hydroxyphenylacetate, a pattern characteristic of bacterial overgrowth syndrome
In addition to an association with low birth weight, there are several linked genetic diseases including overgrowth syndromes
such as Beckwith-Wiedemann syndrome, chromosomally linked conditions (trisomies 2, 8 and 20) and X-linked Simpson-Golabi-Behmel syndrome, type 1 glycogen storage diseases, Li-Fraumeni syndrome, familial adenomatous polyposis (FAP) (3-6) and type 1 neurofibromatosis.
Leslie Biesecker, MD, is an investigator at NHGRI focusing on the molecular and clinical characterization of multiple congenital anomaly syndromes and overgrowth syndromes