Women with TNBC whose tumors overexpress
FIAS2 have a significantly reduced survival, so that targeting this gene is likely to have an impact on disease progression," says Welsh.
To look specifically at the impact on bone loss, the researchers crossed mice bred to overexpress
tumor necrosis factor alpha throughout the body with mice that overexpressed
GILZ in just their mesenchymal stem cells.
This open-label, multi-dose, single-arm, multi-center Phase I, dose-escalation study is being conducted to define the toxicity profile, maximum tolerated dose, pharmacokinetics, immunogenicity, and potential antitumor activity of MGAH22 in patients with refractory HER2-positive breast cancer and patients with other carcinomas that overexpress
HER2 for whom no standard therapy is available.
They estimate that 10% of women with breast cancer overexpress
the FGFR1 gene.
The microorganisms produce the desired L-amino acid and overexpress
Future studies will overexpress
DNA binding, non DNA binding, and alanine/aspartate mutant IK isoforms to determine their effect on IK binding.
In tumours that overexpress
the HER2 gene, targeted therapy against HER2, including lapatinib and trastuzumab, has proved very fruitful but there are a few options for oestrogen receptor-negative HER2-negative breast cancer.
Trastuzumab, sold under the name Herceptin, is a recombinant monoclonal antibody that slows or stops the growth of cancers that overexpress
the HER-2 protein.
Rabinovitch of the University of Washington in Seattle and his colleagues genetically engineered mice to overexpress
a gene responsible for making the antioxidant called catalase.
The investigators also intend to construct derivatives of Lactobacillus helveticus CNRZ32 that overexpress
specific esterase activity.