A significant survival advantage has been identified in patients who overexpress
Glembatumumab vedotin is a fully-human monoclonal antibody-drug conjugate (ADC) that targets glycoprotein NMB (gpNMB), a protein overexpressed
by multiple tumor types, including metastatic melanoma where greater than 80% of patients overexpress
"Women with TNBC whose tumors overexpress
FIAS2 have a significantly reduced survival, so that targeting this gene is likely to have an impact on disease progression," says Welsh.
CAMBRIDGE, Mass., September 13, 2012-Induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress
four genes that make them revert to an immature, embryonic state.
Our pre-clinical studies suggest that MGAH22 may provide significant differentiation from the other HER2-targeted immunotherapeutics, including the ability to treat tumors with relatively low levels of HER2 expression." This open-label, multi-dose, single-arm, multi-center Phase I, dose-escalation study is being conducted to define the toxicity profile, maximum tolerated dose, pharmacokinetics, immunogenicity, and potential antitumor activity of MGAH22 in patients with refractory HER2-positive breast cancer and patients with other carcinomas that overexpress
HER2 for whom no standard therapy is available.
They estimate that 10% of women with breast cancer overexpress
the FGFR1 gene.
The microorganisms produce the desired L-amino acid and overexpress
In tumours that overexpress
the HER2 gene, targeted therapy against HER2, including lapatinib and trastuzumab, has proved very fruitful but there are a few options for oestrogen receptor-negative HER2-negative breast cancer.
Trastuzumab, sold under the name Herceptin, is a recombinant monoclonal antibody that slows or stops the growth of cancers that overexpress
the HER-2 protein.
Rabinovitch of the University of Washington in Seattle and his colleagues genetically engineered mice to overexpress
a gene responsible for making the antioxidant called catalase.
The investigators also intend to construct derivatives of Lactobacillus helveticus CNRZ32 that overexpress
specific esterase activity.
We have utilized an endoprotease-deficient strain of Chinese hamster ovary cells called RPE.40 as a vehicle to overexpress