Reports on BoNTA efficacy for neurogenic detrusor overactivity
and urinary incontinence are very abundant in the literature.
was observed in all patients before therapy.
1- Overactive Bladder-Non Neurogenic Detrusor Overactivity
Keywords: Detrusor overactivity
, Detrusor areflexia, Neurogenic bladder, Spinal cord injury, Urodynamic study/Urodynamics.
 Fentanyl has also been shown in animal studies to have a cardioprotective and anti-arrhythmic effect in sympathetic overactivity
, independent of its haemodynamic effects.
For example, levodopa has been found to exert variable effects on bladder function; acute administration was found to increase sensations of bladder filling and exacerbate detrusor overactivity
in a group of 26 patients with newly diagnosed Parkinson's disease who had not been given the drug previously, while chronic administration reduced sensory urgency (Brusa et al., 2007).
It has been proposed that adipokines such as leptin, tumor necrosis factor alpha, and interleukin-6 produced by the adipose cells may contribute to the sympathetic overactivity
in individuals with higher BMI.
[sup] LUTD is sustained by a complex alteration of the neurological control of the detrusor-sphincter function, resulting in detrusor overactivity
, detrusor hypocontractility, and/or detrusor-sphincter dyssynergia (DSD).
Conclusion: Gegen improved detrusor overactivity
through neurogenic and anti-muscarinic mechanisms.
'Some drugs are available to decrease muscular overactivity
in the bladder.
Urodynamics were obtained, consistent with neurogenic detrusor overactivity
(NDO), detrusor-sphincter dyssynergia (DSD), and symptoms of AD associated with filling.
The editors have organized the eighteen contributions that make up the main body of the text in two sections and four parts devoted to basic science and reconstitution of botulinum neurotoxin and clinical applications of botulinum neurotoxins for the treatment of muscle overactivity
associated with focal dystonia syndromes and upper motor neuron syndromes, neurosecretory disorders, and a wide variety of other related subjects.