ovarian hyperstimulation syndrome


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.

ovarian hyperstimulation syndrome

,

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.
References in periodicals archive ?
Chang, "Ovarian hyperstimulation syndrome complicating a spontaneous singleton pregnanc: a case report," Journal of Assisted Reproduction and Genetics, vol.
No room for cancellation, coasting, or ovarian hyperstimulation syndrome in oocyte donation cycles.
Increased early pregnancy loss in IVF patients with severe ovarian hyperstimulation syndrome. Hum Reprod 2002;17:107-10.
Early timed follicular aspiration prevents severe ovarian hyperstimulation syndrome. J Assist Reprod Genet.
The role of vascular endothelial growth factor and interleukins in the pathogenesis of severe ovarian hyperstimulation syndrome. Hum Reprod Update.
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic, serious complication in women undergoing assisted reproductive technologies (ARTs) for fertility treatment.
Ovarian hyperstimulation syndrome (OHSS) was diagnosed in 30 and 21 woman in groups 1 and 2, respectively (p=0.059).
At the other extreme, a high AMH value (>3.5 ng/mL) predicts a hyper-response to ovarian stimulation with gonadotropins and elevated risk of ovarian hyperstimulation syndrome. In conjunction with clinical and other laboratory findings, an elevated level of AMH also can suggest polycystic ovary syndrome.
Meanwhile, in an analysis of more than 1.1 million cycles between 2000 and 2011 drawn from Centers for Disease Control and Prevention surveillance data, researchers found that the most commonly reported patient complication was ovarian hyperstimulation syndrome (a peak of 154 per 10,000 autologous cycles) and hospitalization (a peak of 35 per 10,000 autologous cycles; JAMA.
The effectiveness and safety of this option have been proved so that this technique is routinely used in ART centers for infertile women to store supernumerary embryos, prevent ovarian hyperstimulation syndrome (OHSS) and in cases of impaired endometrial development and impractical embryo transfer (16, 17).
Ovarian hyperstimulation syndrome (OHSS) is considered an iatrogenic consequence of ovulation induction during the management of infertility during in vitro fertilization (IVF) cycles.