ovarian ablation

ovarian ablation

Ovarian suppression Gynecology Surgery, RT, or chemotherapy to block ovarian hormonal activity
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SAN FRANCISCO -- Ovarian ablation or suppression shows promise as an adjuvant therapy in breast cancer, particularly in premenopausal women with receptor- positive lesions.
Ovarian ablation can be achieved by oophorectomy or radiotherapy, and temporary ovarian suppression can be achieved by the use of LHRH agonists.
The recent improvement in breast cancer survival can be credited to systematic screening programs, greater public awareness, earlier surgery, improved methods of achieving local control, more effective chemotherapy, tamoxifen, ovarian ablation, and advances in radiation therapy, he said at a breast cancer symposium sponsored by the San Antonio Cancer Institute.
For example, for women age 50 and younger, ovarian ablation -- the destruction or removal of the ovaries by radiation or surgery -- proved just as effective as chemotherapy.
11 LANCET urges cancer specialists to reexamined ovarian ablation in light of new findings.
Two proposed etiologies are direct pharmacologic neurotoxicity or loss of estrogen's neurocognitive protective effect secondary to chemotherapy-induced ovarian ablation.