Sertoli cell

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Sertoli cell

(sər-tō′lē, sĕr-)
n.
Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.

Sertoli cell

An elongated cell in the seminiferous tubules of the testis which secretes sex hormone-binding globulin and provides a micro-environment for developing sperm.

Sertoli cells secretions
• Anti-Müllerian hormone—Early foetal life.
• Inhibin and activins—Post-pubertal; regulate FSH secretion.
• Androgen binding protein—Concentrates testosterone in the seminiferous tubules, stimulating spermiogenesis.
• Oestradiol aromatase—Converts testosterone to 17 beta oestradiol for spermatogenesis.
• Glial cell-derived neurotrophic factor—Drives spermatogonial stem cell renewal during perinatal period.
• ERM transcription factor—Maintains spermatogonial stem cell in the adult testis.
• Transferrin—Iron ion delivery.