The main site of damage is the outer hair cells
in the basal turn of the cochlea, where aminoglycosides are received from the lysosomes of the cells' cytoplasm, which leads to the local formation of toxic free radicals and finally to hair cell apoptosis.
Screening for outer hair cell
dysfunction DPOAEs to identify early, potentially preclinical damage.
Permanent threshold shifts are a result of the swelling and deforming of outer hair cells
and alterations in endoplasmic reticulum.
Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells
of a gentamicin metabolite in vitro.
Different stimuli, both internal and external, are capable of producing a depolarization and contraction of the outer hair cells
With exposure to loud noise, the outer hair cells
show a reduction in their ability to function, which may later recover.
Mice lacking FGF20 were missing about twothirds of their outer hair cells
Dr Sung-Ho Huh, from Washington University in St Louis, whose study appeared in the online Library of Science Biology, said: "This is important because most age-related hearing loss is due to the loss of outer hair cells
This is the first evidence that inner and outer hair cells
develop independently of one another," said lead researcher Dr Sung-Ho Huh, from Washington University School of Medicine in St Louis, US.
This line is flanked on one side by three rows of outer hair cells
, which seem to amplify the sound waves that reach the inner cells.
However, in the presence of pro-oxidant chemical agents, we demonstrated that even mild noise can yield oxidative stress leading to the death of sensory receptor cells for sound, the outer hair cells
, and subsequent permanent impairment of auditory function (Fechter et al.
The results show that disabling the gene causes a loss of outer hair cells
, a special type of sensory cell in the inner ear responsible for amplifying sound.