Type 2 diabetes alters the functional status of outer hair cells
in the cochlea.
Distortion-product otoacoustic emissions (DPOAE) are the sounds emitted by the outer hair cells
of the cochlea in response to a pair of simultaneously presented pure-tone stimuli.
The Table summarizes the COMP-VA clinical objectives pertinent to identifying and monitoring changes in hearing and outer hair cell
function (objectives 1-4, listed above).
It has been indicated that the most affected cells are the outer hair cells
Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells
of a gentamicin metabolite in vitro.
Different stimuli, both internal and external, are capable of producing a depolarization and contraction of the outer hair cells
10) Radiation-induced vascular insufficiency has been regarded as the etiology of SNHL, while in animal models the exposure of inner ears to radiation resulted in destruction of outer hair cells
and inner hair cells, atrophy of the stria vascularis and a reduced number of afferent nerve endings.
As outer hair cells
become permanently damaged or nonfunctional, otoacoustic emissions provide greater accuracy and efficiency in predicting cochlear status than the audiogram.
With exposure to loud noise, the outer hair cells
show a reduction in their ability to function, which may later recover.
Mice lacking FGF20 were missing about twothirds of their outer hair cells
Scientists say they can now use the FGF20 gene profile to halt the loss of outer hair cells
Mice lacking FGF20 were missing about two thirds of their outer hair cells