ouabain


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oua·ba·in

(wah-bin, wah'bah-in),
A glycoside and African arrow poison from ouabaio, obtained from the wood of Acocanthera ouabaio or from the seeds of Strophanthus gratus; its action is qualitatively identical to that of strophanthus and the digitalis glycosides; used for rapid digitalization; often used in pharmacologic studies because of water solubility.

ouabain

(wä-bā′ĭn)
n.
A white poisonous glycoside, C29H44O12, extracted from the seeds of certain African trees of the genera Strophanthus and Acokanthera, that is used as a dart poison in some parts of Africa and has been used to treat congestive heart failure.

ouabain

(wă-bā′ĭn)
A glycoside prepared from Strophanthus gratus. Its action is similar to that of digitalis.
References in periodicals archive ?
The (https://www.sciencedaily.com/releases/2018/01/180117164007.htm) American Chemical Society , which publishes the journal, explained that at low levels ouabain is used to regulate blood pressure or treat cardiac patients, but in higher doses can damage the heart.
OUA = ouabain ([Na.sup.+]/[K.sup.+]-ATPase inhibitor, 72.8 [micro]g/mL).
reported that ouabain, a compound in Acokanthera oppositifolia, can induce MDR expression in vitro.
Ouabain targets mainly on the small vessels and the myocardial cell, rather than on the large vessels, and therefore can be useful to distinguish between relevant obstructive coronary atherosclerosis and the actual ischemia in the microvasculature or in the myocardial cell itself.
They found the heart drug ouabain, when administered, can reduce the virus' replication.
Ouabain is a cardiac glycoside which specifically inhibits the [Na.sup.+], [K.sup.+]-ATPase (Mcllwain, 1963).
The a subunit is the catalytic unit and is responsible for binding of [Na.sup.+] and [K.sup.+] ions, ATP, and ouabain (an inhibitor).
Dubai: Ouabain and Baroque -- these are the words Rohan Kapur, 13 and Kavya Prasad,15 swear by these days.
The final assay concentrations of the chemicals used here were 135 mmol Tris-HCl (pH 7.4), 100 mmol NaCl, 10 ouabain, and 6 mmol ATP.
The animals' spiral ganglion neurons had been deliberately destroyed with a drug called ouabain, leaving them completely deaf.