ototoxic


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ototoxic

 [o´to-tok″sik]
having a damaging effect upon the eighth cranial (vestibulocochlear) nerve or on the organs of hearing and balance.

o·to·tox·ic

(ō'tō-tok'sik),
Relating to ototoxicity.

ototoxic

/oto·tox·ic/ (o´to-tok″sik) having a deleterious effect upon the eighth nerve or on the organs of hearing and balance.

ototoxic

(ō′tə-tŏk′sĭk)
adj.
Having a toxic effect on the structures of the ear, especially on its nerve supply.

o′to·tox·ic′i·ty (-tŏk-sĭs′ĭ-tē) n.

ototoxic

adjective Referring to a substance or process that is toxic to the vestibulo-auditory apparatus.

o·to·tox·ic

(ō'tō-tok'sik)
Having a toxic action on the ear.
[oto- + G. toxikon, poison]

Ototoxic

Damaging to the nerves controlling the senses of hearing and balance.
Mentioned in: Tinnitus

ototoxic

having a deleterious effect upon the eighth cranial (vestibulocochlear) nerve or on the organs of hearing and balance.
References in periodicals archive ?
The ototoxic effects of loop diuretics seem to be associated with the stria vascularis, which is affected by changes in the ionic gradients between the perilymph and endolymph.
Effective intervention is needed to improve industrial safety of individuals experiencing ototoxic effects of solvents.
The increasing annual frequency of 300% for new cisplatin-receiving patients who were audiologically monitored during treatment between 2006 and 2010 can be attributed to improved awareness of the ototoxic effects of cisplatin on the part of SA oncologists.
Finally, the presence of mucosal edema and exudates in the middle ear space may protect the round window membrane from contact with potentially ototoxic substances that are placed in the middle ear.
The model included a 3-level MS type factor (RRMS, SPMS, and control), 2-level noise exposure factor (yes and no) and 2-level use of ototoxic medication factor (yes and no).
Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise.
TBI patients often require treatment with drug regimens, such as aminoglycoside antibiotics for infection, that are ototoxic and cause irreversible cochlear and/or vestibular damage.
Occupational exposure to noise and ototoxic organic solvents.
Amoxicillin appears to be a suboptimal choice for chronic non-responders due to its low sensitivity when compared with topical fluoroquinolone eardrops with ear mopping, which covers 95% of organisms cultured and is not ototoxic.
Results indicate that renewed supporting cell proliferation and hair cell regeneration occur in animals that have lost their hearing due to ototoxic or acoustic injury.
3) Risk factors include cumulative drug dose, duration of treatment, bacteraemia, renal or liver failure, and concomitant administration of drugs such as loop diuretics, that have a synergistic ototoxic effect.