SP7

(redirected from osterix)

SP7

A gene on chromosome 12q13.13 that encodes a transcriptional activator required for osteoblast differentiation, binding to SP1 and EKLF consensus sequences and to other GC-rich sequences.
References in periodicals archive ?
This activates the expression of runt-related transcription factor 2 (Runx2) and osterix, which are the key transcription factors that induce osteoblast differentiation.
A 2017 study in Scientific Reports detailed how melatonin regulates the activity of a protein, Osterix, that is crucial to the formation and activity of bone-building cells called osteoblasts.
Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification.
Periodontal fibroblasts strongly expressed osteogenic genes such as ALP, Runx2, osterix and osteocalcin and formed mineralized nodules (10).
To verify osteogenic differentiation of AD-MSCs after 21 days of cultivation in osteogenic medium, we performed relative quantification of gene transcripts of osterix (OSX), bone sialoprotein (BSP), and osteocalcin (OC) by real time RT-PCR using the [2.
According to the results of qRT-PCR, mRNA expression of runt-related transcription factor 2 (Runx2) and Osterix gene, which are characteristic early markers of osteogenesis, was hindered by GC treatment (Figure 3(a)).
MSCs express low, biologically relevant levels of both proadipogenic transcription factors PPAR-[gamma] and C/EBP[alpha] and pro-osteoblast transcription factors such as Runx2 and osterix.
Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I.
Genes that are critical transcription factors and regulators of osteogenesis such as Runx2, osterix (Osx) and LIM domain mineralization protein (LMP) may hold promise in periodontal tissue engineering, especially in alveolar bone augmentation.
After being exposed for 48 h to 100 [micro]g/ml PM extract, 1000 nM genistein, or 1000 nM puerarin, primary baboon osteoblasts markedly increased the rate of proliferation and mRNA levels of ALP and type I collagen without changes in Runx2, osterix, or osteocalcin expression.
The novel zinc finger- containing transcription factor osterix is required for osteoblast differentiation and bone formation.
La hipoxia es una condicion inicial de este microambiente injuriado; la disminucion de oxigeno induce la proliferacion de multiples tipos celulares y determina procesos complejos en los cuales estan involucradas un gran numero de moleculas, entre las que destacan: el factor inducible por hipoxia (HIF), el factor de crecimiento vascular del endotelio (VEGF), el RUNX2, el osterix (Osx), el factor de crecimiento de fibroblastos (FGF), entre otras (3-8).