Bony trabeculae were assessed as either normal, osteosclerotic
, osteopenic, or with mixed osteosclerosis and osteopenia.
The syndrome has a number of characteristic clinical and radiographic signs that differentiate it from other osteosclerotic
lesions were also seen in the skull (Figure 3).
Diseases include chondrosarcomas, metastatic carcinoma to bone, bone cysts, lipomas, achondroplasia, the Ehlers-Danos syndromes, Marfan syndrome, osteosclerotic
disorders, Hunter's disease, clinical gout and hyperuricemia, and hypoparathyroidism.
82%) patients which included genu varum in 9, genu valgum in 2, wind swept deformity in 1, bilateral coxa vara in 1, protrusio acetabulae in 1, fractures in 5, pseudofractures in 3, and lytic bone lesions with osteosclerotic
margin over acetabular roof in 1 patient (Fig.
The mass had a lytic nature with well defined osteosclerotic
boundaries and facet joints were normal (Figure 1).
Reactive sclerosis is often seen with lymphoma, metastatic carcinoma, osteosclerotic
myeloma, Ewing's sarcoma, and osteomyelitis.
Overlap syndromes, formerly known as mixed sclerosing dystrophies, in which OPK and other osteosclerotic
bone disorders (such as fibrous dysplasia, osteopathia striata, and melorheostosis) are combined, must be borne in mind in the differential diagnosis.
of cases Multiple myeloma 330 NSMM 20 Osteosclerotic
myeloma 15 SMM 72 Indolent/evolving myeloma 8 Plasmacytoma (solitary) 22 Extramedullary myeloma 5 Multiple solitary plasmacytoma 3 Macroglobulinemia 9 IgM lymphoproliferative disease 2 IgM lymphoma 5 Smoldering macroglobulinemia 2 Primary systemic amyloidosis 269 LCDD 7 MGUS 114 Idiopathic Bence Jones proteinuria 4 Heavy chain disease 2 Cryoglobulinemia 4 Acquired Fanconi syndrome 3 Scleromyxedema 2 Plasma cell leukemia 1 Table 2.
mice demonstrate a significant decrease in hematopoietic carrying capacity.
Coincident chronic lymphocytic leukemia and osteosclerotic
Neonatal severe osteosclerotic
dysplasia Blomstrand Generalised AR Raine dysplasia Mild craniofacial ?