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Related to osteosarcoma: chondrosarcoma
osteogenic sarcoma. adj., adj osteosarco´matous.
the most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly the ends of long bones; its greatest incidence is in the age group between 10 and 25 years.
n. pl. osteosarco·mata (-mə-tə) or osteosarco·mas
A malignant bone tumor. Also called osteogenic sarcoma.
osteosarcomaA high-grade sarcoma which arises in the metaphysis of long bones and produces malignant osteoid.
Osteosarcomas comprise 2–3% of paediatric malignancies and 20% of all bone cancers; frequency 4–5/106 age range, 5–50 (60% under age 25), more common in males.
Pain, swelling of extremity, pathological fractures.
Metaphysis of long bones (distal femur, proximal tibia, proximal humerus); less commonly in flat bones, facial, pelvic, scapula, spine, short bones.
Usually arises de novo, but may be due to radiation, Paget’s disease of bone, linked to chemotherapy (alkylating agents), pre-existing benign bone lesions (fibrous dysplasia, osteochondromatosis, chondromatosis), foreign bodies (e.g. orthopaedic hardware).
Variable sclerosis and osteolysis, Codman’s triangle.
Pre-op chemotherapy; resect.
Lungs, lymph nodes, other bones.
Very poor; better if 95% of the tumour is necrotic.
• Osteosarcoma NOS (not otherwise specified)
• Fibroblastic (osteofibrosarcoma)
• Central osteosarcoma (conventional central osteosarcoma, medullary osteosarcoma)
• Intracortical osteosarcoma
• Chondroblastic osteosarcoma
• Fibroblastic osteosarcoma
• Giant cell rich osteosarcoma
• Osteoblastic osteosarcoma (osteogenic osteosarcoma)
• Small-cell osteosarcoma
• Telangiectatic osteosarcoma
os·te·o·gen·ic sar·co·ma(os'tē-ō-jen'ik sahr-kō'mă)
The most common and malignant of bone sarcomas, which arises from bone-forming cells and chiefly affects the ends of long bones; its greatest incidence is in the 10-25-year-old age group.
osteosarcomaA highly malignant form of bone cancer that affects mostly young people between the ages of 10 and 20. The tumour is commonest at the lower end of the thigh bone (femur) or the upper end of the shin bone (tibia) causing swelling and sometimes pain, local warmth and tenderness. A characteristic ‘sun-ray’ effect of bone spicules is often visible on X-ray. Early spread to other parts of the body (METASTASIS) is common and unexplained pain or swelling at either of these sites should always be investigated without delay. In confirmed cases, urgent treatment is necessary if life is to be saved.
os·te·o·gen·ic sar·co·ma(os'tē-ō-jen'ik sahr-kō'mă) [MIM*259500]
Most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly ends of long bones.