osteosarcoma


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Related to osteosarcoma: chondrosarcoma

osteosarcoma

 [os″te-o-sahr-ko´mah]
osteogenic sarcoma. adj., adj osteosarco´matous.

os·te·o·gen·ic sar·co·ma

[MIM*259500]
the most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly the ends of long bones; its greatest incidence is in the age group between 10 and 25 years.
Synonym(s): osteosarcoma

osteosarcoma

/os·teo·sar·co·ma/ (os″te-o-sahr-ko´mah) a malignant primary neoplasm of bone composed of a malignant connective tissue stroma with evidence of malignant osteoid, bone, or cartilage formation; it is subclassified as osteoblastic, chondroblastic, or fibroblastic.osteosarco´matous
parosteal osteosarcoma  a variant consisting of a slowly growing tumor resembling cancellous bone but arising from the cortex of the bone and slowly growing outward to surround the bone.
periosteal osteosarcoma  a variant of osteochondroma consisting of a soft, lobulated tumor arising from the periosteum of a long bone and growing outward.
small-cell osteosarcoma  a variant of osteosarcoma resembling Ewing's sarcoma, with areas of osteoid and sometimes chondroid formation.

osteosarcoma

(ŏs′tē-ō-sär-kō′mə)
n. pl. osteosarco·mata (-mə-tə) or osteosarco·mas
A malignant bone tumor. Also called osteogenic sarcoma.

osteosarcoma

[os′tē·ō′särkō′mə]
Etymology: Gk, osteon + sarx, flesh, oma
a malignant tumor of the bone, composed of anaplastic cells derived from mesenchyme. It is the most common type of primary malignant bone tumor, accounting for 35% of such malignancies. It occurs most often in the distal femur. Metastasis to the lung occurs more often in males than in females. It occurs most frequently between the second and fourth decade of life. Also called osteogenic sarcoma.
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Osteosarcoma

osteosarcoma

A high-grade sarcoma which arises in the metaphysis of long bones and produces malignant osteoid.

Epidemiology
Osteosarcomas comprise 2–3% of paediatric malignancies and 20% of all bone cancers; frequency 4–5/106 age range, 5–50 (60% under age 25), more common in males.

Clinical findings
Pain, swelling of extremity, pathological fractures.

Location
Metaphysis of long bones (distal femur, proximal tibia, proximal humerus); less commonly in flat bones, facial, pelvic, scapula, spine, short bones.

Predisposing factors
Usually arises de novo, but may be due to radiation, Paget’s disease of bone, linked to chemotherapy (alkylating agents), pre-existing benign bone lesions (fibrous dysplasia, osteochondromatosis, chondromatosis), foreign bodies (e.g. orthopaedic hardware).

Imaging
Variable sclerosis and osteolysis, Codman’s triangle.

Management
Pre-op chemotherapy; resect.

Metastases
Lungs, lymph nodes, other bones.

Prognosis
Very poor; better if 95% of the tumour is necrotic.

Osteosarcoma types
-Conventional
• Osteosarcoma NOS (not otherwise specified)
• Chondroblastic
• Fibroblastic (osteofibrosarcoma)
• Central osteosarcoma (conventional central osteosarcoma, medullary osteosarcoma)
• Intracortical osteosarcoma
-High-grade superficial
-Low-grade central
-Parosteal (juxtacortical)
-Periosteal (chondroblastic)
-Secondary
-Small cell
-Telangiectatic
-Microscopic variants
• Chondroblastic osteosarcoma
• Fibroblastic osteosarcoma
• Giant cell rich osteosarcoma
• Osteoblastic osteosarcoma (osteogenic osteosarcoma)
• Small-cell osteosarcoma
• Telangiectatic osteosarcoma

os·te·o·gen·ic sar·co·ma

(os'tē-ō-jen'ik sahr-kō'mă)
The most common and malignant of bone sarcomas, which arises from bone-forming cells and chiefly affects the ends of long bones; its greatest incidence is in the 10-25-year-old age group.
Synonym(s): osteosarcoma.

osteosarcoma

A highly malignant form of bone cancer that affects mostly young people between the ages of 10 and 20. The tumour is commonest at the lower end of the thigh bone (femur) or the upper end of the shin bone (tibia) causing swelling and sometimes pain, local warmth and tenderness. A characteristic ‘sun-ray’ effect of bone spicules is often visible on X-ray. Early spread to other parts of the body (METASTASIS) is common and unexplained pain or swelling at either of these sites should always be investigated without delay. In confirmed cases, urgent treatment is necessary if life is to be saved.

osteosarcoma

commonest malignant neoplasm of bone, tending to affect ends of long bones

os·te·o·gen·ic sar·co·ma

(os'tē-ō-jen'ik sahr-kō'mă) [MIM*259500]
Most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly ends of long bones.
Synonym(s): osteosarcoma.

osteosarcoma (os´tēōsärkō´mə),

n a malignant neoplasm of the bone-forming tissues.

osteosarcoma

bone-producing malignant tumor; common in dogs and cats, but rare in other species. Dogs of large breeds are more frequently affected and the most common sites are distal humerus or femur and proximal radius or tibia. Lameness, swelling and rapid metastasis to the lungs are usual features.
References in periodicals archive ?
It can be assumed that if the pathologist who diagnosed GCT with malignancy had had the access to the first diagnosis, he should have made an effort to make abundant sampling in order to prove telangiectatic osteosarcoma.
To the best of our knowledge this is the first case of Osteosarcoma presenting with secondaries in the penis.
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Canine Osteosarcoma Vaccine is a lyophilized formulation of a modified live, attenuated strain of listeria that activates cytotoxic T-cells.
Similar to other extraskeletal osteosarcomas, mammary osteosarcoma may exhibit a variety of histologic features.
Histologic evaluation of treated osteosarcoma focuses on residual osteosarcoma cells on a background of necrosis, calcification, or fibrosis.
All patients received a standard osteosarcoma work-up consisting of blood investigations and imaging before biopsy and then definitive treatment.
Burkitt's lymphoma (60%) and osteosarcoma (55%) were found to affect patients in the age group of 1-20 years.
Conclusion: Ferulic acid could significantly descend osteosarcoma cell viability through the promoting apoptosis pathway in which FA activates both caspase-3 and Bax and inactivates Bcl-2.
In this study, we reviewed matched pretreatment biopsy and postneoadjuvant chemotherapy surgical resection specimens of high-grade osteosarcoma to identify histomorphologic features of prognostic significance.
El caso corresponde a una mujer de 45 anos de edad, quien asistio al servicio de Cirugia Maxilofacial del Hospital Universitario San Ignacio (HUSI) de Bogota, Colombia, el 24 de febrero de 2016, asintomatica, con un cuadro clinico de un mes de evolucion, consistente en el crecimiento rapido de una mucosa posterior al lado izquierdo del maxilar inferior, que venia con un reporte histopatologico extrainstitucional de osteosarcoma fibroblastico de bajo grado.
To homogenize nuclear and environmental factors, we built transmitochondrial cell lines (cytoplasmic hybrids or cybrids) with osteosarcoma 143B or adenocarcinoma A549 [rho.