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os·te·o·pro·teg·er·in (OPG),

Polypeptide suppressing osseous mineral turnover deficient in juvenile onset Paget disease.
[osteo- + L. protego, protegere, to protect, + -in]


A secreted protein that inhibits osteoclast differentiation.
[osteo- + L. protego, protegere, to protect, + -in]

osteoprotegerin (OPG)

A secreted protein which inhibits osteoclast differentiation. The cytokine TRANCE binds to osteoprotegerin. Recombinant osteoprotegerin has been used successfully to treat juvenile PAGET'S DISEASE.
References in periodicals archive ?
Additionally, the mRNA levels for RUNX2 (an osteoblast-specific transcription factor) and osteoprotegerin (a RANKL antagonist) were elevated by LPNS.
Native human osteoprotegerin amino acid sequence, N-terminal signaling peptide (gray) 1 mnkllccalv fldisikwtt qetfppkylh ydeetshqll cdkcppgtyl kqhctakwkt 61 vcapcpdhyy tdswhtsdec lycspvckel qyvkqecnrt hnrvceckeg ryleiefclk 121 hrscppgfgv vqagtpernt vckrcpdgff snetsskapc rkhtncsvfg llltqkgnat 181 hdnicsgnse stqkcgidvt lceeaffrfa vptkftpnwl svlvdnlpgt kvnaesveri 241 krqhssqeqt fqllklwkhq nkdqdivkki iqdidlcens vqrhighanl tfeqlrslme 301 slpgkkvgae diektikack psdqilklls lwrikngdqd tlkglmhalk hsktyhfpkt 361 vtqslkktir flhsftmykl yqklflemig nqvqsvkisc 1
The relationship between osteoprotegerin (OPG) and mortality in heart failure is independent of the conventional cardiovascular risk factors, based on a secondary analysis of results of the Italian GISSI-Heart Failure trial.
The intratympanic corticosteroids might have produced a permanent hearing loss as a result of their effect on osteoprotegerin in the inner ear.
Protelos(R) was found to stimulate the expression of osteoprotegerin (OPG), a protein that inhibits osteoclast (cells responsible for resorbing bone) formation and activity.
Osteoprotegerin serum levels in men: correlation with age, estrogen and testosterone status.
Osteoblasts also produce osteoprotegerin (OPG), a potent inhibitor of osteoclast formation and a decoy receptor for RANK.
10:00 Spaceflight-Induced Osteoporosis in Mouse Bone and Osteoprotegerin Therapy.
Several of the mice will be injected with a protein called osteoprotegerin 24 hours before the flight to determine whether the substance prevents bone loss in a weightless environment.
Research showed that anticholesterol drugs called statins stimulate bone growth and that a protein known as osteoprotegerin prevents bone from breaking down (157: 41*).
In recent years, researchers have clearly uncovered that the receptor activator of NF-[kappa]B (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG) are key regulators of osteoclastic bone resorption in vitro and in vivo (Boyle et al.
Association between osteoprotegerin gene polymorphisim and bone mineral density in patients with adolescent idiopathic scoliosis.