Also found in: Dictionary, Acronyms, Wikipedia.
A secreted phosphoprotein, produced by many epithelial cell types, which is highly negatively charged and frequently associated with mineralization processes. It is found in plasma, urine, milk, and bile. Transformed cells express osteopontin in elevated levels.
Synonym(s): bone sialoprotein 1
A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.
An extracellular matrix glycoprotein (approximate molecular weight 44 to 64 kD). It has been implicated in the pathophysiology of inflammatory, autoimmune, and malignant disorders as well as in wound repair.