osteopontin


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Related to osteopontin: Osteocalcin, Osteonectin

os·te·o·pon·tin

(os'tē-ō-pon'tin),
A secreted phosphoprotein, produced by many epithelial cell types, which is highly negatively charged and frequently associated with mineralization processes. It is found in plasma, urine, milk, and bile. Transformed cells express osteopontin in elevated levels.
Synonym(s): bone sialoprotein 1

osteopontin

(ŏs′tē-ō-pŏn′tn)
n.
A phosphorylated glycoprotein that is produced by bone, is abundant in bone mineral matrix, and accelerates bone regeneration and remodeling. It is also produced in other tissues and plays a role in the progression of many diseases, including certain cancers.

osteopontin

(ŏs″tē-ō-pŏn′tĭn)
An extracellular matrix glycoprotein (approximate molecular weight 44 to 64 kD). It has been implicated in the pathophysiology of inflammatory, autoimmune, and malignant disorders as well as in wound repair.
References in periodicals archive ?
In addition, researchers will test if more translatable delivery of recombinant osteopontin and IGF1 proteins using multifunctional fibers can achieve similar restoration after SCI.
Previous reports show that carotid plaque osteopontin level is a predictor of cardiovascular events after carotid endarterectomy [33] and high levels of it recorded in serum [34].
[6] To compare levels of Cross-sectional osteopontin (OPN), MMP-2, MMP-9, and TIMP-1.
Osteopontin expression levels were slightly, but not significantly, elevated for all ELF-PEMF groups except for CIT number 114 on both days 3 and 7 compared to control.
In this work, we detected 5 DN effector proteins differentially abundant among the three cohorts: osteopontin, neprilysin, fibronectin, kininogen-1, and VCAM-1 (Table 3(a)).
However, serum levels of Dkk-1 and osteopontin did not differ between the two groups (Table 2).
Similarly, the blockage of crystal binding molecules (such as osteopontin, hyaluronic acid, sialic acid, and monocyte chemoattractant protein-1) expressed on epithelial cell membranes may be an alternative approach to prevent stone formation [41].
Partridge, "Regulation of collagenase-3 and osteocalcin gene expression by collagen and osteopontin in differentiating MC3T3-E1 cells," The Journal of Biological Chemistry, vol.
Protective role of osteopontin in endodontic infection.
Osteopontin (OPN) is an extracellular matrix protein with a wide range of functions.
Adiponectin aggravated bone erosions by promoting osteopontin production in RA synovial tissue, suggesting that adiponectin induced the expression of osteopontin, which in turn recruited osteoclasts [58].
Promising biomarkers introduced in recent studies are hyaluronan (13-15), osteopontin (13-20), megakaryocyte potentiating factor (MPF) (15, 18), and mesothelin (13-15, 19-20).

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