Congenital
osteopetrotic mutations as probes of the origin, structure and function of osteoclasts.
Previous studies have shown that Src-deficient mice exhibit an
osteopetrotic phenotype (Soriano et al.
Osteopetrotic mice (op/op), which lack MCSF-1, have been shown to harbor 24% fewer microglia in the cerebral cortex than wild-type controls; however, the microglial morphology was relatively normal [42].
Osteopetrotic (op/op) mice, which are deficient in M-CSF, show a lack of osteoclast development [7].
(1994) Cadmium-induced osteomalacic and
osteopetrotic lesions in overiectomized rats.
Schuler et al., "Identification of macrophages and dendritic cells in the
osteopetrotic (op/op) mouse," JournalofCellScience, vol.104, no.4, pp.1021-1029, 1993.
At an older age, [Rankl.sup.-/-] mice developed rounded faces, likely due to
osteopetrotic changes of the facial skeleton.
Progressive increase in bone mass and development of odontomas in aging
osteopetrotic c-src-deficient mice.
(14) Mice with increased expression of OPG are
osteopetrotic (23) while animals with deficiency of OPG present osteoporosis.
The hard
osteopetrotic bone caused several drill-bits to wear out before a drill duct for a 9 mm intramedullary nail was achieved (Fig.
Inhibition by dithionite and reactivation by iron of the tartrate-resistant acid phosphatase in bone of
osteopetrotic rats.
Effects of vitamin D binding protein-macrophage activating factor (DBP-MAF) infusion on bone resorption in two
osteopetrotic mutations.