Progressive increase in bone mass and development of odontomas in aging osteopetrotic
Effects of vitamin D binding protein-macrophage activating factor (DBP-MAF) infusion on bone resorption in two osteopetrotic
16, 2000), and the paper by Amling et al, "Progressive increase in bone mass and development of odontomas in aging osteopetrotic
c-src-deficient mice" (Bone 27(5), Nov.
Administration of Gc-MAF to osteopetrotic
rodents reversed their bone and immunological defects, probably by activating osteoclasts as well as macrophages (13).
In osteopetrotic rat and mice models (6, 7) and in a single human study (4), indirect data suggested a defect in lysophospholipid-inducible Gc-MAF, although direct estimation of this factor in healthy and diseased states has not been performed.
A defect in the inflammation-primed macrophage-activation cascade in osteopetrotic rats.