mutations as probes of the origin, structure and function of osteoclasts.
Previous studies have shown that Src-deficient mice exhibit an osteopetrotic
phenotype (Soriano et al.
mice (op/op), which lack MCSF-1, have been shown to harbor 24% fewer microglia in the cerebral cortex than wild-type controls; however, the microglial morphology was relatively normal .
(op/op) mice, which are deficient in M-CSF, show a lack of osteoclast development .
(1994) Cadmium-induced osteomalacic and osteopetrotic
lesions in overiectomized rats.
Schuler et al., "Identification of macrophages and dendritic cells in the osteopetrotic
(op/op) mouse," JournalofCellScience, vol.104, no.4, pp.1021-1029, 1993.
At an older age, [Rankl.sup.-/-] mice developed rounded faces, likely due to osteopetrotic
changes of the facial skeleton.
Progressive increase in bone mass and development of odontomas in aging osteopetrotic
(14) Mice with increased expression of OPG are osteopetrotic
(23) while animals with deficiency of OPG present osteoporosis.
The hard osteopetrotic
bone caused several drill-bits to wear out before a drill duct for a 9 mm intramedullary nail was achieved (Fig.
Inhibition by dithionite and reactivation by iron of the tartrate-resistant acid phosphatase in bone of osteopetrotic
Effects of vitamin D binding protein-macrophage activating factor (DBP-MAF) infusion on bone resorption in two osteopetrotic