The search terms were as follows: ("osteonectin
" OR "SPARC glycoprotein" OR "BM-40" OR "basement membrane tumor protein" OR "BM 40 protein" OR "SPARC" OR "secreted protein acidic and rich in cysteine") AND ("neoplasm" OR "neoplasia" OR "tumor" OR "tumour" OR "cancer" OR "carcinoma" OR "malignancy" OR "malignant" OR "cancerous" OR "carcinomatous" OR "cancroid").
 Active substances such as serotonin, catecholamines, von Willebrand factor, proaccelerin, osteonectin
, and antimicrobial proteins released, all of which stimulate cell migration and proliferation within the fibrin matrix, launching the first stages of healing.
Ultra V block (Histostain-Plus Kit, Invitrogen, Carlsbad, CA) was applied for 10 min prior to the application of the primary antibodies (osteonectin
antibody, mouse monoclonal, 1/200, Santa Cruz Biotechnology, or osteopontin antibody, mouse monoclonal, 1/200, Santa Cruz Biotechnology) overnight.
Primers synthesized by Invitrogen for collagen type I (Col1A1), osteonectin
(ON), collagen type II (Col2A1), aggrecan (ACAN), and fatty-acid-binding protein-4 (FABP4) were used in this study (Table 2).
According to recent studies, in contrast to our previous knowledge, vascular calcification is an actively regulated process and human vascular smooth muscle cells can express osteoblastic transcription factors (100,101) and bone-regulating proteins such as matrix Gla protein, osteopontin, osteocalcin, collagen 1, osteonectin
, bone morphogenic proteins, alkaline phosphatase, and bone sialoprotein.
(3) In addition, a mature OB also secretes high levels of osteopontin, osteonectin
, bone sialoprotein, and type I collagen.
PEMFs increased cell proliferation, mineralization, and the expression of differentiation markers, such as Runx2, Osteocalcin, Osteonectin
, and ALP activity.
Thunyakitpisal, "Acemannan stimulates bone sialoprotein, osteocalcin, osteopontin and osteonectin
expression in periodontal ligament cells in vitro," Journal of the Dental Association of Thailand, vol.
The purpose of this study was to analyse in animal model the ability to integrate bone substitutes by evaluating the angiogenesis as revealed by immunohistochemical expression of the platelet endothelial cell adhesion molecules (PECAM-1/CD31) and vascular endothelial growth factor (VEGF) and the scaring and bone remodelling process as revealed by immunohistochemical expression of collagen IV, osteonectin
, and laminin, for three materials generally used for bone augmentation: bovine hydroxyapatite, betatricalcic phosphate, and bioactive glasses.
Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin
, is an albumin-binding protein involved in mediating interactions between cells and their extracellular environment during morphogenesis, tissue remodeling, and angiogenesis .
Weaver et al., "Osteocalcin and osteonectin
immunoreactivity in the diagnosis of osteosarcoma," American Journal of Clinical Pathology, vol.
(1) Trilineage di?erentiation BMP2-induced UC-MSCs have good osteogenic (i) Osteogenesis: osteonectin
, ALP, di?erentiation (indicated and RUNX2 were expressed by the activation of BMP2 signaling) and may be (ii) Chondrogenesis: COL II, used in tissue- collagen type X (COL X), and engineered bone.