There was one patient with osteonecrosis
in the tanezumab 5 mg arm, and no patients in the tanezumab 2.5 mg or NSAIDs arms.
The primary safety endpoint evaluated a composite measure of adjudicated outcomes of RPOA type 1 or type 2, subchondral insufficiency fracture, primary osteonecrosis
or pathological fracture through 80 weeks (56 weeks of treatment plus a 24-week safety follow-up period).
Although the absence of atypical femoral fractures or cases of osteonecrosis
of the jaw is reassuring, the authors note that their trial was underpowered to assess these uncommon events.
of the knee (SONK) was first reported in 1968 by Ahlback. It was defined as a distinct clinical entity with characteristic findings including a subchondral lesion in the weight-bearing region of a single condyle.
Patients and Methods: All cementless total hip arthroplasty (THA) patients operated for Osteonecrosis
of femoral head (ONFH) in UNIT 3 were included.
Findings conducted from this study were positive and significant, as this is the first study to investigate the effects of anti-IL-6 therapy on femoral head osteonecrosis
. The results indicated both a decrease in hip synovitis score and significant increase in bone rebuilding.
The incidence of osteonecrosis
. In: Urbaniak JR, Jones JR, eds.
TUESDAY, May 8, 2018 (HealthDay News) -- For patients with a fibula free tissue transfer (FFTT) for osteoradionecrosis (ORN) and osteonecrosis
(ON) of the mandible, the rate of complications is similar for patients undergoing primary and secondary dental implantation, according to a study published online May 3 in JAMA Facial Plastic Surgery.
of the femoral head (ONFH) was originally described in 1925 as an ischemic necrosis of the hip area .
Excessive glucocorticoid (GC) use is one of the etiologies of osteonecrosis
of the femoral head (ONFH).
Magnetic resonance imaging (MRI) of the left ankle revealed a vertical crack in the talar body extending from the center of the talar dome to the subtalar joint and a lateral talar body fragment with low signal intensity on both T1-weighted and short T1 inversion recovery images suggestive of osteonecrosis
(Figures 2(a) and 2(b)).
applied curved intertrochanteric varus osteotomy to 53 hips with the diagnosis of femoral head osteonecrosis
and reported successful clinical results in a mean follow-up of 6.2 years (17).