New analysis from Frost & Sullivan,Innovations in Bone Healing , finds that novel ceramic and polymer biomaterial technologies have improved the biocompatibility, osteoconduction and osteoinduction
of bone grafts.
While osteoconduction is the ability of a material to support growth of bone over its surface, osteoinduction
is the ability to induce osteogenesis in a non osseous tissue .
The presence of the micropores and rough macropores surface can be seen through the sintered samples which is essential porous to achieve osteoinduction
The massive amounts of cancellous bone that can be obtained from the inner table of the pelvis provide all the desired properties of osteoconduction, osteoinduction
, and osteogenicity.
24) Such grafts are described as possessing all 3 mechanisms that promote bone healing: osteoinduction
, osteoconduction, and osteogenesis.
Matrix GLA protein and BMP-2 regulate osteoinduction
in calcifying vascular cells.
A scaffold structure of well-interconnected pores is important for osteoinduction
by biomaterials .
One way to solve the problem of obtaining elastic porous coatings of required thickness is application of polymer composites (Barinov & Komlev, 2005) consisting of at least two phases: 1) organic phase in the form of bioinert poly-mer bonding agent possessing elasticity, adhesion, bioinertness and ability for sterilization; 2) inorganic phase in the form of bioactive filling consisting of fine-dispersed calcium-phosphate powders of differ-ent chemical composition which stimulate biological processes of osteoinduction
and osteoconduction (Shutov, 2009).
Although the mechanism of osteoinduction
remains unclear, the ionic exchanges properties of the calcium phosphate cement with the surrounding milieu have been pointed out as a relevant parameter, among others.
The rest are organized into sections on calcium phosphate, bioglass, calcium phosphate cements, injectable materials, composites, bioactive titanium and materials, zirconia ceramics, dental materials, scaffolds, osteoinduction
, cell-material interactions, drug delivery, animal studies, and clinical applications.
Classic studies by Marshall Urist (13) demonstrated that demineralized fragments of bone could induce bone formation when placed into skeletal muscle, thereby defining the process known as osteoinduction
Process Monitoring Testing - Microbiological and analytical tests are conducted on pre- and post-processed tissues including bioburden, sterility and bacteriostasis/fungistasis (B/F), microbial IDs, endotoxin, osteoinduction
, skin screening and moisture residual.