Reddi, "Autoradiographic localization of osteogenin
binding sites in cartilage and bone during rat embryonic development," Developmental Biology, vol.
DBM contains active proteins such as bone morphogenetic protein (BMP), transforming growth factor-beta (TGF-b), osteogenin
, insulin-like growth factor, and fibroblast growth factor, which are mostly regarded as members of the TGF-b superfamily.
Breitbart et al (125) conducted experimental trials with TCP ceramic and osteogenin
, an osteoinductive protein as an onlay graft substitute in a rabbit calvarial model.
In the third subclass, and more distantly related to these factors, is BMP-3, which is also called osteogenin
Next, they treated the muscle with osteogenin
and demineralized bone matrix, two substances that promote the growth of bone cells.
Research on a substance called osteogenin could have profound implications for treatment of many human bone-related conditions.
Work on osteogenin originally was performed by cell biologist A.
In 18 animals, the researchers injected the muscle flap with osteogenin
, a naturally occurring protein in bone that scientists believe may play an important role in the development of the fetal skeleton.
The genetically engineered fusion protein is based on a unique bone morphogenetic protein called Osteogenin
, originally developed at the National Institutes of Health (NIH).
The osteogenic potential of two composite graft systems using osteogenin
may be useful in promoting bone ingrowth into prosthetic implants to minimize chances of the devices loosening.
inhibits proliferation and stimulates differentiation in mouse osteoblast-like cells (MC 3T3-E1).