osteogenin

bone morphogenetic protein-3

A protein encoded by BMP3 on chromosome 4q21, which belongs to the transforming growth factor-beta (TGFB) superfamily. It negatively regulates bone density, and antagonises osteogenic BMP induction of osteoprogenitor differentitation and ossification.

osteogenin

An extract from bone that has been used experimentally to induce muscle, cartilage and other soft tissue to transform into bone. Osteogenin is a glycoprotein that can transform muscle flaps placed in moulds into cancellous bone matching the exact shape of the mould.

osteogenin

a morphogenetic bone matrix-derived protein which stimulates bone growth.
References in periodicals archive ?
Reddi, "Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development," Developmental Biology, vol.
DBM contains active proteins such as bone morphogenetic protein (BMP), transforming growth factor-beta (TGF-b), osteogenin, insulin-like growth factor, and fibroblast growth factor, which are mostly regarded as members of the TGF-b superfamily.
Breitbart et al (125) conducted experimental trials with TCP ceramic and osteogenin, an osteoinductive protein as an onlay graft substitute in a rabbit calvarial model.
Next, they treated the muscle with osteogenin and demineralized bone matrix, two substances that promote the growth of bone cells.
Research on a substance called osteogenin could have profound implications for treatment of many human bone-related conditions.
Work on osteogenin originally was performed by cell biologist A.
In 18 animals, the researchers injected the muscle flap with osteogenin, a naturally occurring protein in bone that scientists believe may play an important role in the development of the fetal skeleton.
The genetically engineered fusion protein is based on a unique bone morphogenetic protein called Osteogenin, originally developed at the National Institutes of Health (NIH).
Osteogenin may be useful in promoting bone ingrowth into prosthetic implants to minimize chances of the devices loosening.
Osteogenin inhibits proliferation and stimulates differentiation in mouse osteoblast-like cells (MC 3T3-E1).