osteogenic sarcoma

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 [sahr-ko´mah] (pl. sarcomas, sarco´mata.)
A tumor, often highly malignant, composed of cells derived from connective tissue such as bone, cartilage, muscle, blood vessel, or lymphoid tissue; sarcomas usually develop rapidly and metastasize through the lymph channels. Different types are named for the specific tissue they affect: fibrosarcoma in fibrous connective tissue; lymphosarcoma in lymphoid tissues; osteosarcoma in bone; chondrosarcoma in cartilage; rhabdosarcoma in muscle; and liposarcoma in fat cells. adj., adj sarco´matous.
Abernethy's sarcoma a malignant fatty tumor occurring mainly on the trunk.
alveolar soft part sarcoma one with a reticulated fibrous stroma enclosing groups of sarcoma cells enclosed in alveoli walled with connective tissue.
botryoid sarcoma (sarcoma botryoi´des) an embryonal rhabdomyosarcoma arising in submucosal tissue, usually in the upper vagina, cervix uteri, or bladder neck in young children and infants, presenting grossly as a polypoid grapelike structure.
endometrial stromal sarcoma a pale, polypoid, fleshy, malignant tumor of the endometrial stroma.
Ewing's sarcoma a malignant tumor of the bone that arises in medullary tissue, usually found in cylindrical bones, with pain, fever, and leukocytosis as prominent symptoms; called also Ewing's tumor.
giant cell sarcoma a malignant form of giant cell tumor of bone.
granulocytic sarcoma chloroma.
immunoblastic sarcoma of B cells an aggressive B-cell lymphoma believed to arise from transformed interfollicular B lymphocytes, which in many cases is associated with a preexisting immunologic disorder, e.g., Sjögren's syndrome, systemic lupus erythematosus, or Hashimoto's thyroiditis, or with an immunocompromised state.
immunoblastic sarcoma of T cells a group of T-cell lymphomas comprising tumors derived from T lymphocytes in the paracortical area arising from a mixture of small lymphocytes and many large transformed cells; the latter are characterized by one or more small but distinctly eosinophilic nucleoli.
Kaposi sarcoma a multicentric, malignant neoplastic vascular proliferation characterized by bluish red cutaneous nodules, usually on the lower extremities, most often on the toes or feet; the nodules slowly increase in size and number and spread to more proximal sites. Tumors often remain confined to skin and subcutaneous tissue, but widespread visceral involvement may occur. The condition occurs endemically in certain parts of Central Africa and Central and Eastern Europe, and a particularly virulent and disseminated form occurs in immunocompromised patients such as transplant recipients and those with acquired immunodeficiency syndrome. Human herpesvirus 8 has been implicated as a causative agent.
lymphatic sarcoma diffuse lymphoma.
osteogenic sarcoma a malignant primary tumor of bone composed of a malignant connective tissue stroma with evidence of osteoid, bone, and/or cartilage formation; depending upon the dominant component, classified as osteoblastic, fibroblastic, or chondroblastic.
pseudo–Kaposi sarcoma unilateral subacute to chronic dermatitis, often with postinflammatory hyperpigmentation, occurring in association with underlying arteriovenous fistula, which closely resembles Kaposi sarcoma both clinically and histologically.
reticulum cell sarcoma histiocytic lymphoma.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

os·te·o·gen·ic sar·co·ma

the most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly the ends of long bones; its greatest incidence is in the age group between 10 and 25 years.
Synonym(s): osteosarcoma
Farlex Partner Medical Dictionary © Farlex 2012

osteogenic sarcoma

The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A high-grade sarcoma which arises in the metaphysis of long bones and produces malignant osteoid.

Osteosarcomas comprise 2–3% of paediatric malignancies and 20% of all bone cancers; frequency 4–5/106 age range, 5–50 (60% under age 25), more common in males.

Clinical findings
Pain, swelling of extremity, pathological fractures.

Metaphysis of long bones (distal femur, proximal tibia, proximal humerus); less commonly in flat bones, facial, pelvic, scapula, spine, short bones.

Predisposing factors
Usually arises de novo, but may be due to radiation, Paget’s disease of bone, linked to chemotherapy (alkylating agents), pre-existing benign bone lesions (fibrous dysplasia, osteochondromatosis, chondromatosis), foreign bodies (e.g. orthopaedic hardware).

Variable sclerosis and osteolysis, Codman’s triangle.

Pre-op chemotherapy; resect.

Lungs, lymph nodes, other bones.

Very poor; better if 95% of the tumour is necrotic.

Osteosarcoma types
• Osteosarcoma NOS (not otherwise specified)
• Chondroblastic
• Fibroblastic (osteofibrosarcoma)
• Central osteosarcoma (conventional central osteosarcoma, medullary osteosarcoma)
• Intracortical osteosarcoma
-High-grade superficial
-Low-grade central
-Parosteal (juxtacortical)
-Periosteal (chondroblastic)
-Small cell
-Microscopic variants
• Chondroblastic osteosarcoma
• Fibroblastic osteosarcoma
• Giant cell rich osteosarcoma
• Osteoblastic osteosarcoma (osteogenic osteosarcoma)
• Small-cell osteosarcoma
• Telangiectatic osteosarcoma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

os·te·o·gen·ic sar·co·ma

(os'tē-ō-jen'ik sahr-kō'mă)
The most common and malignant of bone sarcomas, which arises from bone-forming cells and chiefly affects the ends of long bones; its greatest incidence is in the 10-25-year-old age group.
Synonym(s): osteosarcoma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

osteogenic sarcoma

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

os·te·o·gen·ic sar·co·ma

(os'tē-ō-jen'ik sahr-kō'mă) [MIM*259500]
Most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly ends of long bones.
Synonym(s): osteosarcoma.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma. Clin Orthop Relat Res.
All patients with osteogenic sarcoma of lower extremities requiring combined musculoskeletal and soft tissue reconstruction for wound closure in index surgery were included.
Improved outcomes in patients with osteogenic sarcoma of the head and neck.
Primary osteogenic sarcoma of the bladder: Complete review of sarcomata of the bladder.
However it was finally diagnosed as Osteogenic sarcoma of mandible at Tata memorial centre, Mumbai on our referral.
Benign osteoblastoma: a category of osteoid-and bone-forming tumors other than classical osteoid osteoma which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer.
* Osteogenic sarcoma, a malignant tumor most often found in a cat's skull or hind legs, can cause pain, swelling, deformity and lameness.
Although infection is the most common cause of facial swelling, facial masses may indicate rhabdomyosarcoma, Ewing sarcoma, osteogenic sarcoma or metastatic neuroblastoma.
Beverley suffered from osteogenic sarcoma, which meant there was a chance she would develop secondary tumours in her lungs.
Neglia et al (13) explained that "the frequency of such cancers is low compared with the frequency of cancer cures." For example, osteogenic sarcomas that form after radiation exposure account for only 3.1% to 5.5% of all osteogenic sarcoma occurrences.
Tumors can be benign (such as osteoid osteomas or osteoblastomas), malignant (such as Ewing's sarcoma or osteogenic sarcoma), and metastatic (such as neuroblastomas or rhabdomyosarcomas).
A tumor in your knee is osteogenic sarcoma. It's cancer."