osteosarcoma(redirected from osteogenetic sarcoma)
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Related to osteogenetic sarcoma: osteogenesis imperfecta, osteosarcoma, chondrosarcoma, Ewing sarcoma
osteogenic sarcoma. adj., adj osteosarco´matous.
the most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly the ends of long bones; its greatest incidence is in the age group between 10 and 25 years.
osteosarcoma/os·teo·sar·co·ma/ (os″te-o-sahr-ko´mah) a malignant primary neoplasm of bone composed of a malignant connective tissue stroma with evidence of malignant osteoid, bone, or cartilage formation; it is subclassified as osteoblastic, chondroblastic, or fibroblastic.osteosarco´matous
parosteal osteosarcoma a variant consisting of a slowly growing tumor resembling cancellous bone but arising from the cortex of the bone and slowly growing outward to surround the bone.
periosteal osteosarcoma a variant of osteochondroma consisting of a soft, lobulated tumor arising from the periosteum of a long bone and growing outward.
small-cell osteosarcoma a variant of osteosarcoma resembling Ewing's sarcoma, with areas of osteoid and sometimes chondroid formation.
n. pl. osteosarco·mata (-mə-tə) or osteosarco·mas
A malignant bone tumor. Also called osteogenic sarcoma.
Etymology: Gk, osteon + sarx, flesh, oma
a malignant tumor of the bone, composed of anaplastic cells derived from mesenchyme. It is the most common type of primary malignant bone tumor, accounting for 35% of such malignancies. It occurs most often in the distal femur. Metastasis to the lung occurs more often in males than in females. It occurs most frequently between the second and fourth decade of life. Also called osteogenic sarcoma.
osteosarcomaA high-grade sarcoma which arises in the metaphysis of long bones and produces malignant osteoid.
Osteosarcomas comprise 2–3% of paediatric malignancies and 20% of all bone cancers; frequency 4–5/106 age range, 5–50 (60% under age 25), more common in males.
Pain, swelling of extremity, pathological fractures.
Metaphysis of long bones (distal femur, proximal tibia, proximal humerus); less commonly in flat bones, facial, pelvic, scapula, spine, short bones.
Usually arises de novo, but may be due to radiation, Paget’s disease of bone, linked to chemotherapy (alkylating agents), pre-existing benign bone lesions (fibrous dysplasia, osteochondromatosis, chondromatosis), foreign bodies (e.g. orthopaedic hardware).
Variable sclerosis and osteolysis, Codman’s triangle.
Pre-op chemotherapy; resect.
Lungs, lymph nodes, other bones.
Very poor; better if 95% of the tumour is necrotic.
• Osteosarcoma NOS (not otherwise specified)
• Fibroblastic (osteofibrosarcoma)
• Central osteosarcoma (conventional central osteosarcoma, medullary osteosarcoma)
• Intracortical osteosarcoma
• Chondroblastic osteosarcoma
• Fibroblastic osteosarcoma
• Giant cell rich osteosarcoma
• Osteoblastic osteosarcoma (osteogenic osteosarcoma)
• Small-cell osteosarcoma
• Telangiectatic osteosarcoma
os·te·o·gen·ic sar·co·ma(os'tē-ō-jen'ik sahr-kō'mă)
The most common and malignant of bone sarcomas, which arises from bone-forming cells and chiefly affects the ends of long bones; its greatest incidence is in the 10-25-year-old age group.
osteosarcomaA highly malignant form of bone cancer that affects mostly young people between the ages of 10 and 20. The tumour is commonest at the lower end of the thigh bone (femur) or the upper end of the shin bone (tibia) causing swelling and sometimes pain, local warmth and tenderness. A characteristic ‘sun-ray’ effect of bone spicules is often visible on X-ray. Early spread to other parts of the body (METASTASIS) is common and unexplained pain or swelling at either of these sites should always be investigated without delay. In confirmed cases, urgent treatment is necessary if life is to be saved.
osteosarcomacommonest malignant neoplasm of bone, tending to affect ends of long bones
os·te·o·gen·ic sar·co·ma(os'tē-ō-jen'ik sahr-kō'mă) [MIM*259500]
Most common and malignant of bone sarcomas, which arises from bone-forming cells and affects chiefly ends of long bones.
n a malignant neoplasm of the bone-forming tissues.
bone-producing malignant tumor; common in dogs and cats, but rare in other species. Dogs of large breeds are more frequently affected and the most common sites are distal humerus or femur and proximal radius or tibia. Lameness, swelling and rapid metastasis to the lungs are usual features.