Biodentine increases early mineralisation by expressing markers of odontoblasts and induces TGF-Beta1 secretion from pulpal cells in form of osteodentin
. Calcium hydroxide is formed which is responsible for its high pH, provokes the irritation at the area of exposure.
This is possible due to the deposit of mineralized hard tissue composed of osteocement, osteodentin
, or bone or a combination of these three tissues at apical level [6, 7].
Although the replacement resorption and osteodentin
formation are considered pathologic in humans, in this specimen it is physiological and is associated with fast exfoliation and serial tooth irruption.
Any new dentin deposits forming at this time are now similar to osteodentin
; the pulp atrophies and is hyperemic.
Ground section showed dentin like areas which contained dentinal tubules, osteodentin
, enamel space and cementum in a disordered arrangement (Figure 5).
However, on the 30th day, formation of mineralized tissue (dentinal bridge or osteodentin) was observed with complete filling of the exposed sites in the BC/ PLGA group specimens (Figure 2).
After 30 d, osteodentin formation was found, but with discontinuous obstruction of the pulp exposure (Figure 3).
(23-25) Histological studies show that highly mineralized layers of tubular dentin (osteodentin) comprise the reparative dentin.
Induction of hyaline, dysplastic dentinoid material or calcified osteodentin
has been described.