osteoclastic


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Related to osteoclastic: calcitonin, osteoclast activating factor

os·te·o·clas·tic

(os'tē-ō-klas'tik),
Pertaining to osteoclasts, especially with reference to their activity in the absorption and removal of osseous tissue.

os·te·o·clas·tic

(os'tē-ō-klas'tik)
Pertaining to osteoclasts, especially with reference to their activity in the absorption and removal of osseous tissue.

osteoclast

(ŏs′tē-ō-klăst) [″ + klan, to break]
1. A device for fracturing bones for therapeutic purposes.
2. A giant, multinucleated cell derived from blood cell (monocyte) precursors formed in the bone marrow of growing bones. Osteoclasts are found in depressions (called Howship's lacunae) on the surface of the bone. By absorbing calcium salts, they remove excess bone tissue, as in the remodeling of growing bones or damaged bone in the repair of fractures.
osteoclastic (-klăs′tĭk), adjectiveillustration
References in periodicals archive ?
BP have been shown to affect bone metabolism mainly by inhibiting osteoclastic recruitment, activity, and survival.
Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats).
(11,17,21) Decreased osteoblastic and osteoclastic surfaces to bone surface ratios were noted in endocortical, intracortical, and cancellous bone.
(22) Studies in vitro have shown that OPG inhibits the osteoclastogenesis, blocking the bone resorption by mature osteoclast and promoting osteoclastic apoptosis.
Unlike pyrophosphate, however, bisphosphonates actually block normal mineralization as well as osteoclastic bone resorption.
Denosumab, a MoAb against receptor activating NF[kappa]-B (RANK) ligand, inhibits osteoclastic activity in metastatic bone disease.
Tokyo, Japan, Apr 21, 2006 - (JCN) - Novartis Pharma announced on April 20 that it had obtained additional approval for Zometa Injection 4mg, its proprietary osteoclastic inhibitor, from the Ministry of Health, Labor and Welfare.
In addition to osteoclastic isoform TRACP5b, human serum contains another, differently glycosylated isoform, TRACP5a.
PTH stimulates the absorption of bone salts (by increasing bone osteoclastic activity), thereby releasing large amounts of calcium into the ECF.
There may be biologic plausibility for this effect in that both statins and bisphosphonates act in the same metabolic pathway (the mevalonate pathway) that may ultimately affect osteoclastic activity.

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