osteoclastic


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Related to osteoclastic: calcitonin, osteoclast activating factor

os·te·o·clas·tic

(os'tē-ō-klas'tik),
Pertaining to osteoclasts, especially with reference to their activity in the absorption and removal of osseous tissue.

osteoclastic

[-klas′tik]
1 pertaining to osteoclasts.
2 destructive to bone.

os·te·o·clas·tic

(os'tē-ō-klas'tik)
Pertaining to osteoclasts, especially with reference to their activity in the absorption and removal of osseous tissue.

osteoclast

(ŏs′tē-ō-klăst) [″ + klan, to break]
1. A device for fracturing bones for therapeutic purposes.
2. A giant, multinucleated cell derived from blood cell (monocyte) precursors formed in the bone marrow of growing bones. Osteoclasts are found in depressions (called Howship's lacunae) on the surface of the bone. By absorbing calcium salts, they remove excess bone tissue, as in the remodeling of growing bones or damaged bone in the repair of fractures.
osteoclastic (-klăs′tĭk), adjectiveillustration
References in periodicals archive ?
SCI causes significant reduced BMD in long bones due to mechanical unloading whereas the reduction of vertebral BMD is significantly less severe, (23) which shows dominant osteoclastic activities and bone resorption in long bones after SCI.
The osteoclastic giant cell subtype shows intraductal or infiltrating carcinoma contiguous or mixed with spindle cell or sarcomatous stroma plus osteoclastic cells.
Human mesenchymal tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells.
The effect of osteoclastic factors released from tumor cells: The most important factor which activates osteoclastic bone destruction is parathryoid hormone (PTH)-like protein.
Denosumab is a human monoclonal antibody to RANKL (receptor activator of nuclear factor-kB ligand), expressed by osteoclastic giant cells, and is a recent development in the treatment of GCT.
Although some observations identify a direct suppression of vasculogenesis by BPs, it can be difficult in bone to distinguish between inhibition of new vessel growth and suppression of osteoclastic activity because both are coupled.
Tumor giant cells and osteoclastic giant cells are seen (figure 1).
Bioactivity, osteoclastic response of the bioceramic revealed that it would be a promising material for bone tissue engineering.
Normal Al- kaline phosphatase was suggestive of a primarily osteoclastic activity with no attempt at bone formation.
Intravenous zoledronic acid 4 mg was initiated to inhibit the osteoclastic activity and stabilize the bone metastasis.

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