osteoclast-like giant cell


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osteoclast-like giant cell

A multinucleated giant cell with abundant eosinophilic, finely granular or homogeneous cytoplasm containing up to 100 uniform oval nuclei, each measuring 5–7 µm with scattered small nucleoli and peripheral chromatin.
 
DiffDx
Osteoclast-like giant cells are often scattered among plump spindled mononuclear cells and may occur in benign and malignant conditions—e.g., fibrous histiocytoma, Langerhan’s cell histiocytosis, in the mural nodules of mucin-producing ovarian and liver cancer, Hodgkin lymphoma, tumoural calcinosis.
References in periodicals archive ?
Osteoclast-like giant cell tumour of the pancreas: an undifferentiated carcinoma of duct epithelial origin.
Undifferentiated carcinoma with osteoclast-like giant cell tumor of the pancreas: a discussion of rare entity in comparison with pleomorphic giant cell tumor of the pancreas.
Moiraghi et al., "Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: further evidence for a new tumor entity," International Journal of Surgical Pathology, vol.
Atypical fibroxanthoma with osteoclast-like giant cells. Acta Derm Venereol.
An unusual variant with osteoclast-like giant cells. Am J Surg Pathol.
Some of these were engulfed by osteoclast-like giant cells. The background was highly vascular and hemorrhagic, with multiple areas of necrosis.
Clear cell sarcomas frequently display tumoral giant cells but lack the osteoclast-like giant cells of CCSLGT, and up to two-thirds contain melanin pigment.
In Erdheim-Chester disease, the bone marrow is replaced by a proliferation of large, foamy histiocytes embedded in dense fibrous tissue with sparse inflammatory cells and multinucleated, osteoclast-like giant cells. The lesional cells infiltrate the host trabecular bone, which appears thickened.
To diagnose pleomorphic carcinoma with osteoclast-like giant cells, extensive sampling may be required to demonstrate carcinomatous areas.
In addition, variable numbers of scattered osteoclast-like giant cells and brisk osteoblastic rimming of the trabecular bone were noted.
Histologically, osteoclast-like giant cells, spindle cells, and lymphocytes were haphazardly scattered within a myxoid or collagenized background substance showing chondro-osteoid changes.
A reading of representative hematoxylin-eosin-stained sections revealed the following features common to all cases: (1) the presence of variable numbers of multinucleated osteoclast-like giant cells within the lesion; (2) a companion population of mononuclear histiocytes, some with deep nuclear clefts or grooves, the karyomorphism of Langerhans cells; and (3) a component of neutrophilic and eosinophilic granulocytes in varying proportions.
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