Osteoclast-like giant cell tumour of the pancreas: an undifferentiated carcinoma of duct epithelial origin.
Undifferentiated carcinoma with osteoclast-like giant cell tumor of the pancreas: a discussion of rare entity in comparison with pleomorphic giant cell tumor of the pancreas.
Moiraghi et al., "Clear cell sarcoma-like tumor with osteoclast-like giant cells
in the small bowel: further evidence for a new tumor entity," International Journal of Surgical Pathology, vol.
Atypical fibroxanthoma with osteoclast-like giant cells. Acta Derm Venereol.
An unusual variant with osteoclast-like giant cells. Am J Surg Pathol.
Some of these were engulfed by osteoclast-like giant cells
. The background was highly vascular and hemorrhagic, with multiple areas of necrosis.
Clear cell sarcomas frequently display tumoral giant cells but lack the osteoclast-like giant cells
of CCSLGT, and up to two-thirds contain melanin pigment.
In Erdheim-Chester disease, the bone marrow is replaced by a proliferation of large, foamy histiocytes embedded in dense fibrous tissue with sparse inflammatory cells and multinucleated, osteoclast-like giant cells
. The lesional cells infiltrate the host trabecular bone, which appears thickened.
To diagnose pleomorphic carcinoma with osteoclast-like giant cells
, extensive sampling may be required to demonstrate carcinomatous areas.
In addition, variable numbers of scattered osteoclast-like giant cells
and brisk osteoblastic rimming of the trabecular bone were noted.
Histologically, osteoclast-like giant cells
, spindle cells, and lymphocytes were haphazardly scattered within a myxoid or collagenized background substance showing chondro-osteoid changes.
A reading of representative hematoxylin-eosin-stained sections revealed the following features common to all cases: (1) the presence of variable numbers of multinucleated osteoclast-like giant cells
within the lesion; (2) a companion population of mononuclear histiocytes, some with deep nuclear clefts or grooves, the karyomorphism of Langerhans cells; and (3) a component of neutrophilic and eosinophilic granulocytes in varying proportions.