osteoclast


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osteoclast

 [os´te-o-klast″]
1. a large, multinuclear cell frequently associated with resorption of bone.
2. a surgical instrument used for osteoclasis. adj., adj osteoclas´tic.

os·te·o·clast

(os'tē-ō-klast'),
1. A large multinucleated cell, possibly of monocytic origin, with abundant acidophilic cytoplasm, functioning in the absorption and removal of osseous tissue. Synonym(s): osteophage
2. An instrument used to fracture a bone to correct a deformity.
[osteo- + G. klastos, broken]

osteoclast

(ŏs′tē-ə-klăst′)
n.
1. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.
2. An instrument used in surgical osteoclasis.

os′te·o·clas′tic adj.

osteoclast

A cell responsible for reabsorption of bone matrix, which has a central role in bone remodeling.
 
Morphology
Very large (±100 µm in diameter). It has multiple, relatively uniform, but widely separated round or ovoid nuclei with one or more nucleoli, dense chromatin, abundant blue or purple to pale-pink cytoplasm with many fine red-purple granules.

Origin
Osteoclasts derive from monocyte/macrophage precursors and are unrelated to osteoblasts. Their physiologyic role of bone resorption is linked to charge-coupled proton pumps that secrete acid into the extracellular space.

os·te·o·clast

(os'tē-ō-klast)
1. A large multinucleated cell, possibly of monocytic origin, with abundant acidophilic cytoplasm, functioning in the absorption and removal of osseous tissue.
Synonym(s): osteophage.
2. An instrument used to fracture a bone to correct a deformity.
[osteo- + G. klastos, broken]

osteoclast

1. A giant cell containing many nuclei and capable of bone destruction and absorption. Osteoclasts work in conjunction with OSTEOBLASTS in the process of normal bone growth and in bone repair after fractures.
2. A surgical instrument used to fracture bone.

osteoclast

  1. a multinucleate ameoboid cell that breaks down bone during growth and remodelling.
  2. (also called Chomdrioclast) same kind that breaks down cartilage in the transformation to bone.

Osteoclast

Cell that absorbs bone.
Mentioned in: Multiple Myeloma

os·te·o·clast

(os'tē-ō-klast)
1. Large multinucleated cell, with abundant acidophilic cytoplasm, functioning in absorption and removal of osseous tissue.
2. An instrument used to fracture bone to correct a deformity.
References in periodicals archive ?
Correlations between macrophage polarizing cytokines, inflammatory mediators, osteoclast activity, and toll-like receptors in tissues around aseptically loosened hip implants.
Klauschen et al., "Sphingosine-1phosphate mobilizes osteoclast precursors and regulates bone homeostasis," Nature, vol.
Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitors.
Liu et al., "Activation of mTORC1 in B lymphocytes promotes osteoclast formation via regulation of [beta]-catenin and RANKL/OPG," Journal of Bone and Mineral Research, vol.
Qi, "Osteoclast and its roles in calcium metabolism and bone development and remodeling," Biochemical and Biophysical Research Communications, vol.
* But with aging, loss of sex hormones (estrogen and testosterone), and oxidative stress, the activity of bone-forming osteoblasts diminishes, while bone resorption by osteoclasts continues at the same rate, or even increases.
Osteoblasts and stromal cells are involved in osteoclastogenesis through their cell-cell interactions with osteoclast progenitors (Ma et al., 2001).
These compounds prevented bone resorption by inhibiting the formation and function of osteoclast. Therefore, liensinine and nuciferine may be promising protective and therapeutic agents for patients with breast cancer and the related bone loss.
IL-27 also had an effect in inhibiting osteoclast formation in a cell culture assay for osteoclastogenesis.