5,8-11) These classifications have typically been used to characterize OCLs of the talus (OCLT), describing the degree of osteochondral
involvement and the location of the lesion.
Lateral ankle ligament reconstruction Ankle arthroscopy with debridement Microfracture of osteochondral
defects Reconstruction of cavovarus foot Reconstruction of planovalgus foot Excision of osteophytes
2012, 2014b) showed that cartilage-related genes were more highly expressed in their ex vivo cultured osteochondral
explant compared to cartilage-only explants.
Recent progress in interfacial tissue engineering approaches for osteochondral
showed that all patients with osteochondral
defects who received BM-MSCs transplanted on platelet-rich fibrin glue (PR-FG) had a significant improvement in their functional knee scores and MRI findings after 6 months and remained stable 12 months post operation.
In terms of constructing biopolymer scaffolds to repair the osteochondral
defects, recent advances have attempted to mimic the physical structures (e.
1) Pare is credited with first describing the removal of osteochondral
fragments from joints in 1840.
At postoperative follow-up, MRI was obtained demonstrating a vertically oriented osteochondral
fracture measuring 10 mm in greatest dimension with less than 2 mm chondral step off and partial tearing of the medial patellar retinaculum (Figure 2).
Chondral and osteochondral
lesions at the knee joint surface represent a severe medical as well as socioeconomic dilemma.
The first, titled Perforated osteochondral
allograft compositions, US Patent Number 9,168,140, covers donated osteochondral
tissue with a bone and cartilage layer perforated with small holes to allow for cellular migration and osteochondral
ChondroMimetic is a collagen based implant for the treatment of small osteochondral
(cartilage and underlying bone) defects and had previously received CE-mark approval for the treatment of small chondral and subchondral lesions.
Creatine kinase is also recommended for use as an indicator for lameness via carpal osteochondral
fragmentation in horses (Chaney et al.