Phosphorus is mediated mainly in SMCs by PiT1, which causes VSMCs to lose expression of the SM contractile proteins a-SMA and SM22 and instead express the bone markers Runx2, osteocalcin
, and ALP, thereby causing vascular calcification.
The mineralized nodules and osteocalcin
levels were vital osteogenic indicators.
Serum total osteocalcin
(OC) was measured with a BGP immunoradiometric assay kit (Mitsubishi Chemical Medience Corp.
Elevated plasma osteocalcin
levels following ovariectomy have been reported in previous studies [7-10] A similar finding was observed in the present study in the Ovx group; however, the alendronate group showed no change in the plasma osteocalcin
levels, compared to the Shm group.
Results: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin
, and androstenedione levels were significantly increased in the PCOS group.
is a protein that accounts for 25% of the non-collagenous proteins in bone.
When healthy 12 and 15-month-old mice were given osteocalcin
, their running performance matched threemonth-olds.
Previous studies have shown that osteocalcin
communicates with beta cells in the pancreas, which regulate the body's glucose metabolism," he said.
This resulted in a gradual reduction of serum ALP from 1500 U/L to 112 U/L [Figure 3], and normalization of osteocalcin
and urinary deoxypyridinoline levels [Table 1] over an 18 month period with a considerable improvement in his clinical symptoms.
In this study, we report baseline reference range values for Glucose, Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), Creatine Kinase (CK), Gamma-glutamyltransferase (GGT), Albumin (ALB), Creatinine, Blood Urea Nitrogen (BUN), Intact Parathyroid Hormone (N-PTH), Osteocalcin
(OC), Undercarboxylated Osteocalcin
(UCOC) and Total Iron binding capacity (TIBC) in healthy (n=60), lame (n=31) and bone-fractured (n=20) racing camels.
Two bone turnover markers--serum bone-specific alkaline phosphatase (BALP) and osteocalcin
(OC)--declined in the dried-plum group.
Samples were also collected from these recruited subjects to evaluate their bone turn over markers, including, osteocalcin
, procollagen type 1 N propeptide and Beta-Crosslaps.