osteocalcin

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os·te·o·cal·cin

(os'tē-ō-kal'sin),

A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis.

Synonym(s): bone Gla protein

Farlex Partner Medical Dictionary © Farlex 2012

osteocalcin

(ŏs′tē-ō-kăl′sĭn)

A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. It may also act as a hormone to increase insulin production and insulin sensitivity.

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.

os·te·o·cal·cin

(os'tē-ō-kal'sin)

Protein found in osteoblasts and dentin.

Medical Dictionary for the Dental Professions © Farlex 2012

References in periodicals archive ?

"In the healthy adult population, about 30% of the circulating osteocalcin occurs in its undercarboxylated form, and increased vitamin K intake results in rapid decline of ucOC, suggesting a state of subclinical vitamin K deficiency in healthy bone tissue.

Thoughts at Large: Controversies in Clinical Nutrition and Functional Medicine Issue # 12 VITAMIN K1 VERSUS THE MK-7 VERSION OF VITAMIN K2 SUPPLEMENTATION: WHICH IS BEST FOR YOUR PATIENTS?

In sensitivity analyses, in order to distinguish how biomarkers of bone resorption and bone formation influenced each other, the association of children's U-Cd at 9 y of age with urinary DPD (Model 1) was additionally adjusted for osteocalcin, and the association of the U-Cd with osteocalcin was additionally adjusted for DPD.

Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children

Studies in mice showed that moderate exercise, such as walking, triggers the release of osteocalcin in the body.

Exercises may improve memory through a bone hormone

BMD and serum intact osteocalcin in postmenopausal osteoporosis women.

ASSOCIATION OF SERUM P1NP (N-TERMINAL PROPEPTIDE OF TYPE1 COLLAGEN) AND BONE MINERAL DENSITY (BMD) IN OSTEOPOROSIS

Osteocalcin was expressed in the cytoplasm of OSA and OPBT tumour cells (Figure 1) and also on the osteoid.

The Role of Osteocalcin and Alkaline Phosphatase Immunohistochemistry in Osteosarcoma Diagnosis

Lal, "Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women," Journal of Clinical and Diagnostic Research, vol.

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

(2) Increased bone turnover was present if any of the following occurred in combination: serum osteocalcin > 25.3 ng/ml and/or total alkaline phosphate > 130 U/L (bone formation marker) and urinary calcium excretion > 4 mg/kg/day.

Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients

The mineralized nodules and osteocalcin levels were vital osteogenic indicators.

Proliferation and osteogenic activity of fibroblasts induced with fibronectin

Undercarboxylated osteocalcin (ucOC), a sensitive marker of vitamin K status, is correlated with age ([9,10]) and the risk of hip fracture in women ([10]).

Androgen deprivation therapy induces vitamin K loss in men with prostate cancer

Results: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group.

Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance/Polikistik over sendromlu hastalarda insulin direncinde osteokalsin, tumor nekroz faktoru-alfa ve adiponektinin rolu

Bone metabolism was evaluated by determining serum levels of osteocalcin (OC) as a marker of bone formation, and urinary pyrilinks-D (PYD) and beta-CrossLaps (B-CTx) as markers of bone resorption (18).

Bone mineral density in relation to metabolic syndrome components in postmenopausal women with diabetes mellitus type 2

We measured both C-telopeptide of type I collagen (CTX-I) and osteocalcin levels via electrochemiluminescence immunoassay method.

Which predicts quadriceps muscle strength in knee osteoarthritis: biological markers or clinical variables?