osteocalcin


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os·te·o·cal·cin

(os'tē-ō-kal'sin),
A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis.
Synonym(s): bone Gla protein

osteocalcin

(ŏs′tē-ō-kăl′sĭn)
n.
A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. It may also act as a hormone to increase insulin production and insulin sensitivity.

osteocalcin

[-kal′sin]
a protein found in the extracellular matrix of bone and dentin and involved in regulating mineralization in the bones and teeth.

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.

os·te·o·cal·cin

(os'tē-ō-kal'sin)
Protein found in osteoblasts and dentin.

osteocalcin (os´tēōkal´sin),

n vitamin Kdependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism.

osteocalcin

a product of the resorption of bone.
References in periodicals archive ?
Phosphorus is mediated mainly in SMCs by PiT1, which causes VSMCs to lose expression of the SM contractile proteins a-SMA and SM22 and instead express the bone markers Runx2, osteocalcin, and ALP, thereby causing vascular calcification.
The mineralized nodules and osteocalcin levels were vital osteogenic indicators.
Serum total osteocalcin (OC) was measured with a BGP immunoradiometric assay kit (Mitsubishi Chemical Medience Corp.
Elevated plasma osteocalcin levels following ovariectomy have been reported in previous studies [7-10] A similar finding was observed in the present study in the Ovx group; however, the alendronate group showed no change in the plasma osteocalcin levels, compared to the Shm group.
Osteocalcin is a protein that accounts for 25% of the non-collagenous proteins in bone.
When healthy 12 and 15-month-old mice were given osteocalcin, their running performance matched threemonth-olds.
Previous studies have shown that osteocalcin communicates with beta cells in the pancreas, which regulate the body's glucose metabolism," he said.
This resulted in a gradual reduction of serum ALP from 1500 U/L to 112 U/L [Figure 3], and normalization of osteocalcin and urinary deoxypyridinoline levels [Table 1] over an 18 month period with a considerable improvement in his clinical symptoms.
In this study, we report baseline reference range values for Glucose, Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), Creatine Kinase (CK), Gamma-glutamyltransferase (GGT), Albumin (ALB), Creatinine, Blood Urea Nitrogen (BUN), Intact Parathyroid Hormone (N-PTH), Osteocalcin (OC), Undercarboxylated Osteocalcin (UCOC) and Total Iron binding capacity (TIBC) in healthy (n=60), lame (n=31) and bone-fractured (n=20) racing camels.
Two bone turnover markers--serum bone-specific alkaline phosphatase (BALP) and osteocalcin (OC)--declined in the dried-plum group.
Samples were also collected from these recruited subjects to evaluate their bone turn over markers, including, osteocalcin, procollagen type 1 N propeptide and Beta-Crosslaps.