osteocalcin


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os·te·o·cal·cin

(os'tē-ō-kal'sin),
A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis.
Synonym(s): bone Gla protein

osteocalcin

(ŏs′tē-ō-kăl′sĭn)
n.
A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. It may also act as a hormone to increase insulin production and insulin sensitivity.

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.

os·te·o·cal·cin

(os'tē-ō-kal'sin)
Protein found in osteoblasts and dentin.
References in periodicals archive ?
"In the healthy adult population, about 30% of the circulating osteocalcin occurs in its undercarboxylated form, and increased vitamin K intake results in rapid decline of ucOC, suggesting a state of subclinical vitamin K deficiency in healthy bone tissue.
In sensitivity analyses, in order to distinguish how biomarkers of bone resorption and bone formation influenced each other, the association of children's U-Cd at 9 y of age with urinary DPD (Model 1) was additionally adjusted for osteocalcin, and the association of the U-Cd with osteocalcin was additionally adjusted for DPD.
Studies in mice showed that moderate exercise, such as walking, triggers the release of osteocalcin in the body.
Osteocalcin was expressed in the cytoplasm of OSA and OPBT tumour cells (Figure 1) and also on the osteoid.
Lal, "Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women," Journal of Clinical and Diagnostic Research, vol.
(2) Increased bone turnover was present if any of the following occurred in combination: serum osteocalcin > 25.3 ng/ml and/or total alkaline phosphate > 130 U/L (bone formation marker) and urinary calcium excretion > 4 mg/kg/day.
The mineralized nodules and osteocalcin levels were vital osteogenic indicators.
Undercarboxylated osteocalcin (ucOC), a sensitive marker of vitamin K status, is correlated with age ([9,10]) and the risk of hip fracture in women ([10]).
Bone metabolism was evaluated by determining serum levels of osteocalcin (OC) as a marker of bone formation, and urinary pyrilinks-D (PYD) and beta-CrossLaps (B-CTx) as markers of bone resorption (18).
We measured both C-telopeptide of type I collagen (CTX-I) and osteocalcin levels via electrochemiluminescence immunoassay method.