osteocalcin


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os·te·o·cal·cin

(os'tē-ō-kal'sin),
A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis.
Synonym(s): bone Gla protein

osteocalcin

(ŏs′tē-ō-kăl′sĭn)
n.
A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. It may also act as a hormone to increase insulin production and insulin sensitivity.

osteocalcin

[-kal′sin]
a protein found in the extracellular matrix of bone and dentin and involved in regulating mineralization in the bones and teeth.

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.

os·te·o·cal·cin

(os'tē-ō-kal'sin)
Protein found in osteoblasts and dentin.

osteocalcin (os´tēōkal´sin),

n vitamin Kdependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism.

osteocalcin

a product of the resorption of bone.
References in periodicals archive ?
Muyzer and his colleagues had hoped to isolate the osteocalcin and then determine its amino acid sequence.
Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia.
2] by increasing proliferation and expression of ALP, type I collagen, and osteocalcin genes, consistent with those found in primary human osteoblasts (O'Shaughnessy et al.
The concentration of osteocalcin increased significantly in weeks 4 and 8 after surgery in all groups in which rats had been ovariectomized.
9% reduction in inactive osteocalcin levels, while a 9.
3]-inhibited Runx2 protein expression (Figure 3B), ALP activity (Figure 3C), osteoblast mineralization (Figure 3D), and Bmp2 (Figure 4A) and osteocalcin (Figure 4B) mRNA expression during osteoblast differentiation.
This is the first time osteocalcin and osteonectin immunohistochemical staining has been described in avian tissues, to our knowledge.
Also, RT--PCR studies revealed the expression of the osteogenic markers, osteocalcin and osteopontin.
Biochemical Status (Collagen I, Osteocalcin, and Alkaline Phosphatase)
In the case of a slip, trip, or fall, the force of the impact on a bone physically deforms a pair of joined proteins, osteopontin and osteocalcin, and results in the formation of nanoscale holes.
Safety and tolerability were primary endpoints, and secondary endpoints included RA disease response measurements: ACR, DAS28, CRP, and ESR, as well as bone turnover markers, CTx, PINP, and osteocalcin.
The changes in levels of osteocalcin and procollagen type 1 N-terminal propeptide over the 48-week period were significantly inversely correlated with loss of BMD in the lumbar spine.