Phosphorus is mediated mainly in SMCs by PiT1, which causes VSMCs to lose expression of the SM contractile proteins a-SMA and SM22 and instead express the bone markers Runx2,
osteocalcin, and ALP, thereby causing vascular calcification.
The mineralized nodules and
osteocalcin levels were vital osteogenic indicators.
Serum total
osteocalcin (OC) was measured with a BGP immunoradiometric assay kit (Mitsubishi Chemical Medience Corp.
Elevated plasma
osteocalcin levels following ovariectomy have been reported in previous studies [7-10] A similar finding was observed in the present study in the Ovx group; however, the alendronate group showed no change in the plasma
osteocalcin levels, compared to the Shm group.
Results: Homeostasis model assessment (HOMA)-IR, adiponectin,
osteocalcin, and androstenedione levels were significantly increased in the PCOS group.
Osteocalcin is a protein that accounts for 25% of the non-collagenous proteins in bone.
When healthy 12 and 15-month-old mice were given
osteocalcin, their running performance matched threemonth-olds.
Previous studies have shown that
osteocalcin communicates with beta cells in the pancreas, which regulate the body's glucose metabolism," he said.
This resulted in a gradual reduction of serum ALP from 1500 U/L to 112 U/L [Figure 3], and normalization of
osteocalcin and urinary deoxypyridinoline levels [Table 1] over an 18 month period with a considerable improvement in his clinical symptoms.
In this study, we report baseline reference range values for Glucose, Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), Creatine Kinase (CK), Gamma-glutamyltransferase (GGT), Albumin (ALB), Creatinine, Blood Urea Nitrogen (BUN), Intact Parathyroid Hormone (N-PTH),
Osteocalcin (OC), Undercarboxylated
Osteocalcin (UCOC) and Total Iron binding capacity (TIBC) in healthy (n=60), lame (n=31) and bone-fractured (n=20) racing camels.
Two bone turnover markers--serum bone-specific alkaline phosphatase (BALP) and
osteocalcin (OC)--declined in the dried-plum group.
Samples were also collected from these recruited subjects to evaluate their bone turn over markers, including,
osteocalcin, procollagen type 1 N propeptide and Beta-Crosslaps.
