osteocalcin

Also found in: Dictionary, Encyclopedia, Wikipedia.

os·te·o·cal·cin

(os'tē-ō-kal'sin),

A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis.

Synonym(s): bone Gla protein

osteocalcin

(ŏs′tē-ō-kăl′sĭn)

A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. It may also act as a hormone to increase insulin production and insulin sensitivity.

osteocalcin

[-kal′sin]

a protein found in the extracellular matrix of bone and dentin and involved in regulating mineralization in the bones and teeth.

BGLAP

A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1–2% of bone protein, which binds strongly to apatite and calcium.

os·te·o·cal·cin

(os'tē-ō-kal'sin)

Protein found in osteoblasts and dentin.

osteocalcin (os´tēōkal´sin),

n vitamin Kdependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism.

osteocalcin

a product of the resorption of bone.

References in periodicals archive ?

Phosphorus is mediated mainly in SMCs by PiT1, which causes VSMCs to lose expression of the SM contractile proteins a-SMA and SM22 and instead express the bone markers Runx2, osteocalcin, and ALP, thereby causing vascular calcification.

Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure

The mineralized nodules and osteocalcin levels were vital osteogenic indicators.

Proliferation and osteogenic activity of fibroblasts induced with fibronectin

Serum total osteocalcin (OC) was measured with a BGP immunoradiometric assay kit (Mitsubishi Chemical Medience Corp.

Androgen deprivation therapy induces vitamin K loss in men with prostate cancer

Elevated plasma osteocalcin levels following ovariectomy have been reported in previous studies [7-10] A similar finding was observed in the present study in the Ovx group; however, the alendronate group showed no change in the plasma osteocalcin levels, compared to the Shm group.

The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Results: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group.

Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance/Polikistik over sendromlu hastalarda insulin direncinde osteokalsin, tumor nekroz faktoru-alfa ve adiponektinin rolu

Osteocalcin is a protein that accounts for 25% of the non-collagenous proteins in bone.

Effects of jump training on bone and calcium and phosphorus metabolism in rats fed a phosphorus enriched diet

When healthy 12 and 15-month-old mice were given osteocalcin, their running performance matched threemonth-olds.

Hormone jab 'can help the old exercise'

Previous studies have shown that osteocalcin communicates with beta cells in the pancreas, which regulate the body's glucose metabolism," he said.

Running May Be Better Than Cycling for Long-Term Bone Health

This resulted in a gradual reduction of serum ALP from 1500 U/L to 112 U/L [Figure 3], and normalization of osteocalcin and urinary deoxypyridinoline levels [Table 1] over an 18 month period with a considerable improvement in his clinical symptoms.

Paget's disease in an Omani: long-term improvement following a single injection of Zoledronic acid

In this study, we report baseline reference range values for Glucose, Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), Creatine Kinase (CK), Gamma-glutamyltransferase (GGT), Albumin (ALB), Creatinine, Blood Urea Nitrogen (BUN), Intact Parathyroid Hormone (N-PTH), Osteocalcin (OC), Undercarboxylated Osteocalcin (UCOC) and Total Iron binding capacity (TIBC) in healthy (n=60), lame (n=31) and bone-fractured (n=20) racing camels.

ALTERED SERUM ENZYMES AND BIOCHEMICAL LEVELS IN ARABIAN RACING CAMELS WITH BONE FRACTURES

Two bone turnover markers--serum bone-specific alkaline phosphatase (BALP) and osteocalcin (OC)--declined in the dried-plum group.

Dried plums for bones

Samples were also collected from these recruited subjects to evaluate their bone turn over markers, including, osteocalcin, procollagen type 1 N propeptide and Beta-Crosslaps.

HEALTHY LOOKIG HOSPITAL NURSES SHOWING VITAMIN D DEFICIENCY: CORRELATION OF VITAMIN D LEVELS WITH THEIR LEVELS OF PARATHHYROID HORMONE AND BONE TURNOVER MARKERS