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Hypertrophic osteoarthropathy is a syndrome that manifests as clubbing of the fingers, polyarthralgia of the large joints, and ostealgia of the tubular bones; HOA is characterized by periosteal proliferation (1-3).
[2] Current studies regarding KOA pain mechanism mostly focus on the following three aspects: (i) synovial inflammation: pro-inflammatory cytokines such as histamine, prostaglandins, leukotriene, neuropeptides may activate nociceptor to induce pain; (ii) ostealgia: subchondral bone and marrow vessels and nerves exposure caused by KOA articular surface cartilage denudation may also lead to pain; (iii) decreased pain threshold: chronic pain in KOA demonstrates a decreased pain threshold, which can give rise to an increased pain intensity by pain stimulation in the same intensity (hyperalgesia) and even by non-painful stimulation (allodynia).
Physicians believe that Uni-PTH is also more effective in managing ostealgia (bone pain) when compared to current treatments; in clinical studies patients reported that they felt better after treatment with Uni-PTH.
In Persian kondur, from Greek [chi][??]v[delta][rho][OMICRON][zeta], in French encens, is used as oil for ostealgia, muscle cramps, and amnesia and is used for memory enhancer.
Quadro 1 : Principais manifestacoes da sindrome do climaterio Manifestacoes Sintomatologia Neurogenicas Ondas de calor Sudorese Calafrios Palpitacoes Cefaleia Tonturas Parestesia Insonia Falta de memoria Fadiga Psicogenicas Depressao Ansiedade Irritabilidade Diminuicao da libido Metabolicas Osteoporose Aterosclerose Mamarias Mastalgia Mastodinia Urogenitais Secura vaginal Dispareunia Prurido vulvar Corrimento (vagina senil) Sangramento uterino disfuncional Metrorragia pos-menopausa Sindrome uretral Incontinencia urinaria de esforco Osteo-musculo-articulares Ostealgia Artralgia Mialgia Tegumentares Atrofia epidermica Fonte: Halbe (2000).