Differential diagnosis included traumatic muscle injury with hematoma, infectious myositis, myositis ossificans
, and soft tissue neoplasm.
Subjects were excluded if they had current ligamentous defects, history of a sprain of grade II or worse, history of ligament or joint reconstruction or repair, trauma (including fracture, myositis ossificans
or burns), or dysfunction of the vestibular system affecting balance.
Daiichi Sankyo Company, Limited (hereafter Daiichi Sankyo) announced today that the research that it is jointly conducting with Saitama Medical University (Main campus: Hidaka-shi, Saitama Prefecture) to create innovative therapies for fibrodysplasia ossificans
progressiva (FOP) has been adopted for support under the Cyclic Innovation for
Japanese researchers from Kyoto University will start the world's first clinical trial of a drug developed from iPS (induced pluripotent stem) cells with the aim of treating the rare bone disease fibrodysplasia ossificans
Classic and atypical fibrodysplasia ossificans
progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.
The differential diagnosis of neck masses with these findings includes paragangliomas, schwannomas, lymphadenopathy, branchial cysts, lymphangiomas, rhabdomyosarcomas, arteriovenous malformation, or myositis ossificans
Traumatic injury, a more acute and potentially harmful occurrence than entheseal changes, includes bone fractures and myositis ossificans
The scientists started with a very different goal: to create a cellular model to study fibrodysplasia ossificans
Clementia Pharmaceuticals, a company focused on developing palovarotene for fibrodysplasia ossificans
progressive (FOP) and other diseases, has announced top-line results from its Phase two clinical trial investigating palovarotene intended for the treatment of FOP, it was reported yesterday.
These included: (1) a left-sided osteoma of the internal auditory meatus (figure 1, A); (2) a right-sided labyrinthitis ossificans
in a patient with previous meningitis (figure 1, B); and (3) bilateral cochlear calcification, worse on the right than the left, in a patient with a clinical diagnosis of otosclerosis.
infection 02 04 02 Deep infection 03 00 03 Implant failure 00 01 04 Ulnar nerve involvement (Temporary) 04 02 05 Myositis ossificans
00 00 06 Non-union of supracondylar region 00 01 07 Non-union of olecranon osteotomy 00 00
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans