osmotic nephrosis

os·mot·ic ne·phro·sis

swelling of renal tubular epithelium associated with glomerular filtration of sugars and dextrose; the swelling is due to formation of cytoplasmic vesicles by pinocytosis, and is reversible, probably with no dysfunction, when corrected by glucose or mannitol therapy.

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Some of these cases were subsequently proven by renal biopsy to be consistent with osmotic nephrosis. The characteristic histology (sucrose nephropathy) is described and shown below.

Certain rare conditions may be seen in higher numbers than usual as a consequence of the shortages induced, e.g., osmotic nephrosis.

Nephrologic impact of Hurricanes Katrina and Rita in areas not directly affected

Because HOCM and other high-osmolar solutions can cause a distinct histological pattern with vacuolization of tubular cells (osmotic nephrosis) these alterations were thought to rely on osmotic forces.

Contrast media viscosity versus osmolality in kidney injury: lessons from animal studies

It also appears to be capable of producing acute tubular injury, leading to osmotic nephrosis and acute tubular necrosis.