osmotic fragility


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fragility

 [frah-jil´ĭ-te]
susceptibility, or lack of resistance, to influences capable of causing disruption of continuity or integrity.
fragility of blood erythrocyte fragility.
capillary fragility abnormal susceptibility of capillary walls to rupture with extravasation.
erythrocyte fragility unusual susceptibility of erythrocytes to hemolysis under certain conditions; see mechanical fragility and osmotic fragility.
mechanical fragility unusual susceptibility of certain erythrocytes to hemolysis under mechanical stress.
osmotic fragility susceptibility of certain erythrocytes to hemolysis when exposed to increasingly hypotonic solutions; seen in some forms of hemolytic anemia and spherocytosis. A test of osmotic fragility is used in diagnosis of some types of hemolytic anemia.

os·mot·ic fra·gil·i·ty

the susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.

osmotic fragility

Red blood cell osmotic fragility test Hematology The susceptibility of RBCs to osmotic lysis; in hypotonic solutions, RBCs behave as perfect osmometers, where the free water rapidly equilibrates, causing the RBCs to swell. See Hereditary spherocytosis.

os·mot·ic fra·gil·i·ty

(oz-mot'ik fră-jil'i-tē)
The susceptibility of erythrocytes to hemolyze when exposed to increasingly hypotonic saline solutions.
Synonym(s): fragility of the blood.
References in periodicals archive ?
Siddiqui, "Antioxidant vitamins and lipoperoxidation in non-pregnant, pregnant, and gestational diabetic women: erythrocytes osmotic fragility profiles," Journal of Clinical Medicine Research, vol.
A significantly higher osmotic fragility compared to that of the control (p less than 0.05) was also noted.
The effect of vitamin C on arterial blood pressure, irreversibly sickled cells (ISCs), and osmotic fragility in sickle cell anemic subjects also suggests a potential benefit of vitamin C supplementation to sickle cell anemia subjects because vitamins A, C, and E supplementation was shown to decrease arterial blood pressure, % ISCs (irreversibly sickled cells), and MCHC (mean corpuscular hemoglobin concentration) but increased Hb (hemoglobin) and PCV (packed cell volume) [45, 46].
[10] KIM, H.; ISAACKS, R The osmotic fragility and critical haemolytic volume of red blood cells of amazon fishes.
The osmotic fragility of erythrocytes was measured in heparinized blood by suspending the red cells at different concentrations of sodium chloride ranging from 0.8 to 0.1 per cent.
Results of modified one tube osmotic fragility test (OF) and dichlorophenolindophenol precipitate (DCIP) test, hematological analyses for 12 participants.
A A peripheral blood osmotic fragility test has traditionally been considered important in the workup of hereditary spherocytosis (HS).
Naked eye single tube red cell osmotic fragility test for beta thalassemia population survey.
Variations of the Erythrocyte Osmotic Fragility in Cattle Grazing on Pastures with Low Selenium Content with or without Supplement with Selenium
Correlation between serum carnitine levels and erythrocyte osmotic fragility in hemodialysis patients.