Egg maturation undergoes remarkable cytological changes including the formation of a separation cavity, an osmiophilic
egg envelope, a fertilization pore and prominent nuclear evaginations.
Type I secretory granules are large osmiophilic
membrane-bound granules; type II secretory granules are small with electron-dense spherical granules.
The stored mucopolysaccharide substance is finely granular to flocculent and moderately electrondense, whereas the lipid material appears as osmiophilic
multilamellar bodies or fragments of membrane-like material.
The diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) was excluded with high certainty, because granular osmiophilic
deposits in the capillaries, which are diagnostic for CADASIL, were not observed.
Electron microscopy (EM) of a full-thickness skin biopsy revealed granular osmiophilic
material (GOM) embedded within the basement membranes of several arterioles, indenting the cell membranes of the vascular smooth-muscle cells, and fragmentation of the vascular smooth-muscle cells and thickening of the basal membranes (Fig.
The affected vessels develop extensive granular osmiophilic
deposits within the basal membrane (Figure 6), and the arteriopathy leads to widespread demyelination of the white matter and subcortical lacunar infarctions.
Electron microscopy of muscle biopsy showed prominent lysosomal vacuoles containing osmiophilic
granular material, curvilinear bodies and disruption of banding pattern consisting with myopathic alterations with prominent autophagic activity but no specific pathologic diagnosis.
Golgi cisternae with large number of vesicles filled with osmiophilic
contents were observed, which were finally secreted in the lumen of the gland.
II-5 Production Processes II-6 From Animal and Vegetable Fats II-6 The Soap Making Process II-6 Biosynthesis of Glycerol from Glucose II-6 As a Co - Product of Various Products II-6 Production of Glycerol through Carbon - 13 Dioxide II-6 Conversion of Glycerophosphocholine to Glycerol II-6 The Sulfite Process II-6 Fermentation by Osmiophilic
Yeast II-7 Purification of Glycerin II-7
spheroid bodies and crystalline inclusions of variable shapes may be detected in the cytoplasm of endothelial and mesangial cells.
Subsequently, an osmiophilic
egg envelope is formed, from a combination of the products of sheets of endoplamic reticulum and osmiophilic
bodies in the egg cytoplasm.
Orbicules and lipid bodies are both osmiophilic
and appear electron-dense in TEM micrographs.