osmiophilic

os·mi·o·phil·ic

(oz'mē-ō-fil'ik),
Readily stained with osmic acid.
[osmium + G. phileō, to love]

osmiophilic

(ŏz″mē-ō-fĭl′ĭk)
Having an affinity for the staining material osmium tetroxide.
References in periodicals archive ?
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe lysosomal disease caused by mutations in the CLN1 gene, which encodes the soluble lysosomal enzyme Palmitoyl- Protein-Thioesterase-1 (PPT1) and result in osmiophilic granules accumulating in lysosomes and leading to neuroinflammation, neurodegeneration and death.
About Infantile Batten Disease: Infantile neuronal ceroid lipofuscinosis (INCL) is a severe lysosomal disease caused by mutations in the CLN1 gene, which encodes the soluble lysosomal enzyme Palmitoyl-Protein-Thioesterase-1 (PPT1) and result in osmiophilic granules accumulating in lysosomes and leading to neuroinflammation, neurodegeneration and death.
Ultrastructural analysis shows intracellular osmiophilic, lamellated membrane structures with a concentric pattern called myelin bodies or with elongated stripes called zebra bodies.
sup][1],[2] Pathological changes include deposition of granular osmiophilic material on the surface of smooth muscle cells with subsequent fibrosis in the wall of arterioles.
Small perforating cerebral arteries are most frequently affected, with an accumulation of granular and osmiophilic substances within the vascular smooth muscle cell membrane (VSMC) as the basic pathological finding [19,20].
7a), for example, it contained compact and smooth cell wall layers, typical elliptical chloroplasts containing 8-12 grana with large and plump osmiophilic granules, and the mitochondria showed an elliptical shape in intracellular compartment (Fig.
Type I secretory granules are large osmiophilic membrane-bound granules; type II secretory granules are small with electron-dense spherical granules.
The diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) was excluded with high certainty, because granular osmiophilic deposits in the capillaries, which are diagnostic for CADASIL, were not observed.
Electron microscopy (EM) of a full-thickness skin biopsy revealed granular osmiophilic material (GOM) embedded within the basement membranes of several arterioles, indenting the cell membranes of the vascular smooth-muscle cells, and fragmentation of the vascular smooth-muscle cells and thickening of the basal membranes (Fig.
Electron microscopy of muscle biopsy showed prominent lysosomal vacuoles containing osmiophilic granular material, curvilinear bodies and disruption of banding pattern consisting with myopathic alterations with prominent autophagic activity but no specific pathologic diagnosis.
Ultrastructurally, the thrombocytes appear as elliptical or spherical cells containing Golgi, much smooth endoplasmic reticulum, small mitochondria, dense osmiophilic granules, microtubules at the outermost zone of the cell and large vacuoles connected to the canalicular system or opened to the surface.