orthotoluidine

orthotoluidine

metabolite of prilocaine; prilocaine overdose (i.e. > 600mg, = 150% maximum safe dose for 70-kg adult) causes fetal methaemoglobinaemia (orthotoluidine crosses the placenta); safe practice requires prilocaine use to be avoided in pregnant women and children

orthotoluidine

References in periodicals archive ?
DOTG (diorthotolyl guanidine)--DOTG contains up to 1% orthotoluidine, which is listed by IARC as a Group 2B possible human carcinogen
Blood glucose concentrations were measured at 0, 4, 8 and 12 h after drug treatment by the orthotoluidine method (Hultman, 1995; Hyavariner et al.