Chen et al., "Cytosporone B is an agonist for nuclear
orphan receptor Nur77," Nature Chemical Biology, vol.
The report provides comprehensive information on the Atypical Chemokine Receptor 3 (Chemokine
Orphan Receptor 1 or G-Protein Coupled Receptor 159 or G-Protein Coupled Receptor RDC1 Homolog or GPR159 or CXCR7), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
REV-ERB[alpha] binds as a monomer to the retinoic acid receptor-related
orphan receptor (ROR) response elements (ROREs) composed of a 6 bp A/T-rich sequence immediately preceding a site with the core motif of (A/G)GGTCA [3].
suggest that resistin can bind the receptor tyrosine-kinase-like
orphan receptor (ROR1) in murine pre 3T3-L1 adipocytes [34].
Investigators at Boston University School of Medicine (BUSM) and Veterans Affairs (VA) Boston Healthcare System, which reported the first positive results of a genome-wide association study (GWAS) of PTSD, suggested that variations in the retinoid-related
orphan receptor alpha (RORA) gene are linked to the development of PTSD.
The Wnt receptor CRD domain is also found in MuSK and related
orphan receptor tyrosine kinases.
The mouse estrogen receptor-related
orphan receptor alpha 1: molecular cloning and estrogen responsiveness.
It is agreed that the master regulator of Th17 development is retinoic acid-related
orphan receptor.
A significant association was identified between alterations in the RAR-related
orphan receptor beta (RORB) gene, one of the circadian clock genes, and having bipolar disorder.
A significant association was identified between alterations in the RAR-related
orphan receptor beta (RORB) gene, a circadian clock genes, and having bipolar disorder.
There are two classes of retinoid receptor, the RAR or retinoic acid receptor, which binds all-transretinoic acid, and RXR, or the so-called
orphan receptor whose ligand is believed to be 9-cis-retinoic acid.