orphan receptor


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

or·phan re·cep·tor

(ōr'făn rĕ-sep'tŏr)
A nuclear receptor for which no ligand has yet been identified.
Mentioned in ?
References in periodicals archive ?
Chen et al., "Cytosporone B is an agonist for nuclear orphan receptor Nur77," Nature Chemical Biology, vol.
The report provides comprehensive information on the Atypical Chemokine Receptor 3 (Chemokine Orphan Receptor 1 or G-Protein Coupled Receptor 159 or G-Protein Coupled Receptor RDC1 Homolog or GPR159 or CXCR7), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
REV-ERB[alpha] binds as a monomer to the retinoic acid receptor-related orphan receptor (ROR) response elements (ROREs) composed of a 6 bp A/T-rich sequence immediately preceding a site with the core motif of (A/G)GGTCA [3].
suggest that resistin can bind the receptor tyrosine-kinase-like orphan receptor (ROR1) in murine pre 3T3-L1 adipocytes [34].
Investigators at Boston University School of Medicine (BUSM) and Veterans Affairs (VA) Boston Healthcare System, which reported the first positive results of a genome-wide association study (GWAS) of PTSD, suggested that variations in the retinoid-related orphan receptor alpha (RORA) gene are linked to the development of PTSD.
The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
The mouse estrogen receptor-related orphan receptor alpha 1: molecular cloning and estrogen responsiveness.
It is agreed that the master regulator of Th17 development is retinoic acid-related orphan receptor.
A significant association was identified between alterations in the RAR-related orphan receptor beta (RORB) gene, one of the circadian clock genes, and having bipolar disorder.
A significant association was identified between alterations in the RAR-related orphan receptor beta (RORB) gene, a circadian clock genes, and having bipolar disorder.
There are two classes of retinoid receptor, the RAR or retinoic acid receptor, which binds all-transretinoic acid, and RXR, or the so-called orphan receptor whose ligand is believed to be 9-cis-retinoic acid.