orphan nuclear receptor

orphan nuclear receptor

member of the family of nuclear hormone receptor that have no known ligand. Some (for example, steroidogenic factor 1, DAX-1) have been associated with human diseases.
References in periodicals archive ?
The NR4A family is an orphan nuclear receptor because the endogenous ligands of these receptors are not identified [2].
Damiola, Luis-Lopez-Molina et al., "The orphan nuclear receptor REV-ERB[alpha] controls circadian transcription within the positive limb of the mammalian circadian oscillator," Cell, vol.
The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone alpha-subunit gene in pituitary gonadotropes.
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.
One of these receptors, the nuclear receptor subfamily 1, group I, member 3 (NR1I3, also known as the Constitutive Androstane Receptor, CAR), is an orphan nuclear receptor that was first characterized as a cell "xenosensor," and considered a master regulator of drug metabolism and excretion (1).
REV-ERB[alpha] is known to cross-talk with ROR[alpha] (orphan nuclear receptor encoded by nr1f1), another of the clock genes that has similar DNA binding specificity to REV-ERB[alpha] and competes for the binding of REV-ERB[alpha] [14-16].
FXR was first isolated as a mammalian orphan nuclear receptor due to not identifying its ligands, with heterodimeric association to retinoid X receptor [5].
ERR[alpha] belongs to the NR3B orphan nuclear receptor subgroup, which consists of ERR[alpha], ERR[beta], and ERR[gamma] (Hong et al.
The keynote lecture provides an introduction to the nuclear receptor superfamily and the remaining contributions discuss such topics as metabolic control by LXR receptors, regulation of cardiac energetic by the orphan nuclear receptors ERR-alpha and ERR-gamma, FXR and bile acids as critical modulators of metabolisms, the role of PPARs in human prediabetes, the role of the intestine in reverse cholesterol transport, NR4A nuclear receptors in the vessel wall, cholesterol as a novel target in the treatment of Alzheimer's disease, PPAR-gamma mediated effects in central nervous system disorders, and the role of the orphan nuclear receptor rev-erb-alpha in the molecular biology of circadian rhythms and cardiometabolic disease.
The 5-LOX gene has been shown to carry a response element for the orphan nuclear receptor RORalpha (for its RORalpha1 isoform in particular) in its promoter region.
O'Malley, who worked in collaboration with researchers from Duke University Medical Center in Durham, N.C., says that SRC-2 works with an orphan nuclear receptor ROR alpha to affect the activity of the sugar-converting enzyme, glucose-6-phosphatase in the liver.