orphan gene


Also found in: Wikipedia.

orphan gene

a member of the nuclear receptor family for which no ligands have been identified by homology. The gene is so named because the ligands are unknown.
Mentioned in ?
References in periodicals archive ?
It's likely that some orphan gene clusters produce enzymes that could make new antibiotics.
Working with scientists at Scripps Institution of Oceanography at the University of California-San Diego; Oregon State University; and Northland College, in Ashland, Wisconsin, Loper investigated a new method for determining the products of orphan gene clusters.
To do this, the scientists label the chemical building blocks with isotopes and then place the labeled molecules in a culture of the Pseudomonas bacterium that has the orphan gene cluster.
A joint project conducted by Loper and Harry Gross, at the University of Bonn, Germany, demonstrated that a second Pseudomonas orphan gene cluster codes for biosynthesis of compounds related to rhizoxin--an antibiotic and potential antitumor substance.
Pseudomonas: orphan gene clusters offer potential protection against plant diseases
During early regenerative growth, genes called orphan genes are active, Anoop Kumar of University College London and colleagues report October 26 in Nature Communications.
It becomes tempting to think that amniotes are hiding a latent capacity to perform complex regeneration, and the correlation with a potential molecular mechanism, orphan genes, points to a good place to start.
Regeneration was once widespread: ancient amphibians regrew limbs like salamanders do
We will test hypotheses about: (1) the primary drivers of gene content evolution, (2) the repeatability of patterns in gene loss and retention after WGD, and (3) the early evolution of orphan genes.
FraxiFam: Reconstructing gene family evolution in the ash genus (Fraxinus
These so-called orphan genes could have a tremendous amount to do with diversification of animal lineages, but people just pooh-pooh these differences and focus on the things that are shared," he says.
Biology's big bang had a long fuse: animals started evolving long before showing up as fossils

Medical browser ?
Full browser ?