orotic acid


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orotic acid

 [o-rot´ik]
an intermediate in the biosynthesis of pyrimidine nucleotides.

o·rot·ic ac·id (Oro),

(ōr-ot'ik as'id),
6-Carboxyuracil; uracil-6-carboxylic acid; an important intermediate in the formation of the pyrimidine nucleotides; elevated in certain inherited defects of pyrimidine biosynthesis.

o·rot·ic ac·id

(ōr-ot'ik as'id)
An important intermediate in the formation of the pyrimidine nucleotides; elevated in certain inherited defects of pyrimidine biosynthesis.
References in periodicals archive ?
Urine orotic acid and plasma amino acid panel were ordered to investigate her unexplained hyperammonemia.
Late-season skim milk led to a greater increase in FEUA, compared with either ultrafiltered skim milk or early-season skim milk, suggesting that the acute urate-lowering effect of orotic acid may explain these effects.
Thus, this enzyme would provide CP not only to the arginine de novo biosynthetic pathway but also to the orotic acid pathway for the de novo biosynthesis of pyrimidine nucleotides.
HS-induced alterations in nucleotide-related metabolites (orotic acid, uridine 5' -monophosphate, uric acid, adenosine monophosphate, uridine, and uracil) were also observed, with the concentrations increased 1.46- to 2.26-fold in the HS group as compared with the non-HS group (p<0.01).
In this case, the chromatogram was notable for a large peak of orotic acid (OA) eluting at approximately 17 min (Fig.
Blood gas, blood sugar, plasma acyl carnitine profile, blood lactate level, plasma and urine amino acids, urine organic acids, urine ketone and urinary orotic acid levels should initially be tested in cases of high ammonia level for the diagnosis of UCD.
Comment: Orotate (orotic acid) is an intermediate in pyrimidine biosynthesis, and has been reported to have cardioprotective effects.
An organic acid analysis of the patient's urine showed massive excretion of orotic acid and uracil, and an amino acid analysis showed a glutamine concentration > 1500 [micro]mol/L.
We purchased the following compounds from Sigma: adenine, adenosine, 2-deoxyadenosine, 2-deoxyguanosine, inosine, 2-deoxyinosine, xanthine, hypoxanthine, orotic acid, uric acid, thymine, uracil, dihydrothymine, dihydrouracil, N-carbamyl-[beta]-aminoisobutyric acid, N-carbamyl-[beta]-alanine, thymidine, uridine, pseudouracil, 5-hydroxymethyluracil, and 2-deoxyuridine.
This method for the quantification of glutamine in plasma supplements the measurements of plasma ammonia and urine orotic acid commonly used to monitor patients with urea cycle defects.