orotate phosphoribosyltransferase

or·o·tate phos·pho·ri·bo·syl·trans·fer·ase

a phosphoribosyltransferase synthesizing orotidylate and pyrophosphate from orotate and 5-phospho-α-d-ribosyl-1-pyrophosphate; this enzyme is a part of pyrimidine biosynthesis; a deficiency of this enzyme is associated with orotic aciduria type I. Compare: uridylic acid synthase.
References in periodicals archive ?
coli K-12 that requires pyrimidine in minimal growth medium, due to suboptimal expression ofthe enzyme orotate phospho-ribosyltransferase coded for by the orotate phosphoribosyltransferase (pyrE) gene (16).
In the analysis of urine from patients with orotic acidurias caused by orotate phosphoribosyltransferase (EC 2.
It could be caused by the inhibition of orotate phosphoribosyltransferase by accumulating abnormal metabolites.