orotate phosphoribosyltransferase

or·o·tate phos·pho·ri·bo·syl·trans·fer·ase

a phosphoribosyltransferase synthesizing orotidylate and pyrophosphate from orotate and 5-phospho-α-d-ribosyl-1-pyrophosphate; this enzyme is a part of pyrimidine biosynthesis; a deficiency of this enzyme is associated with orotic aciduria type I. Compare: uridylic acid synthase.
References in periodicals archive ?
coli K-12 that requires pyrimidine in minimal growth medium, due to suboptimal expression ofthe enzyme orotate phospho-ribosyltransferase coded for by the orotate phosphoribosyltransferase (pyrE) gene (16).
S-1 is a novel oral anti-cancer drug that combines three pharmacological agents: (1) tegafur, which, after absorption, is converted into the anti-cancer agent 5-FU; (2) gimeracil (CDHP), a dihydropyrimidine dehydrogenase (DPD) inhibitor to prevent degradation of 5-FU; and (3) oteracil (Oxo), an orotate phosphoribosyltransferase (OPRT) inhibitor that reduces the incidence of 5-FU-induced GI toxicity.
In the analysis of urine from patients with orotic acidurias caused by orotate phosphoribosyltransferase (EC 2.
It could be caused by the inhibition of orotate phosphoribosyltransferase by accumulating abnormal metabolites.