oropharyngeal


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oropharyngeal

 [o″ro-fah-rin´je-al]
1. pertaining to the mouth and the pharynx.
2. pertaining to the oropharynx.

or·o·pha·ryn·ge·al

(ōr'ō-fă-rin'jē-ăl), Avoid the incorrect phrase oral pharyngeal and the mispronunciation oropharynge'al.
Relating to the oropharynx.

anthrax

Greek, anthrax, a burning coal, charbon, milzbrand Infectious disease An often fatal bacterial infection which occurs when Bacillus anthracis endospores, primarily of grazing herbivore–cattle, sheep, horses, mules–origin enter via skin abrasions, inhalation, or orally Pathogenesis Anthrax endospores germinate within macrophages, become vegetative bacteria, multiply within the lymphatics, enter the bloodstream and cause massive septicemia Clinical URI-like symptoms, followed by high fever, vomiting, joint pain, SOB, internal and external hemorrhage, hypotension, meningitis, pulmonary edema, shock sudden death; intestinal anthrax is caused by ingestion of contaminated meat; cutaneous anthrax is rare Diagnosis ELISA for capsule antigens–95+% senstivity, for protective antigen–72% sensitivity; detection of exotoxins in blood is unreliable Prevention Prophylaxis–6 wks with doxycycline or ciprofloxacin; vaccination, with anthrax vaccine absorbed; decontamination with aerosolized formalin Management Penicillin, doxycycline; if allergic to penicillin, chloramaphenicol, erythromycin, tetracycline, ciprofloxacin See Bacillus anthracis, Cutaneous anthrax, Industrial anthrax, Inhalation anthrax.
Anthrax, clinical forms
Pulmonary
Almost universally fatal–due to inhalation of anthrax spores which germinate and produce toxins resulting in pleural effusions, hemorrhage, cyanosis, SOB, stridor, shock, death
Inhalation
Anthrax pneumonia, inhalational anthrax, pulmonary anthrax An almost universally fatal form due to inhalation of 1 to 2 µm pathogenic endospores which are deposited in alveoli, engulfed by macrophages and germinate en route to the mediastinal and peribronchial lymph nodes, produce toxins Clinical Mediastinal widening, pleural effusions, fever, nonproductive cough, myalgia, malaise, hemorrhage, cyanosis, SOB, stridor, shock, death, often accompanied by mesenteric lymphadenitis, diffuse abdominal pain, fever
Cutaneous
Once common among handlers of infected animals, eg farmers, woolsorters, tanners, brushmakers and carpetmakers in an era when brushes were from animals Clinical Carbuncle–a cluster of boils, that later ulcerates, resulting in a hard black center surrounded by bright red inflammation; rare cases which become systemic are almost 100% fatal
Gastrointestinal
After ingesting contaminated meat–2 to 5 days; once ingested spores germinate, causing ulceration, hemorrhagic and necrotizing gastroenteritis Clinical Fever, diffuse abdominal pain with rebound tenderness, melanic stools, vomit, fluid and electrolyte imbalances, shock; death is due to intestinal perforation or anthrax toxemia
Oropharyngeal
Uncommon, follows ingestion of contaminated meat Clinical Cervical edema, lymphadenopathy–causing dysphagia, respiratory difficulty
Anthrax meningitis
A rare, usually fatal complication of GI or inhalation anthrax with death occurring 1 to 6 days after onset of illness Clinical Meningeal symptoms, nuchal rigidity, fever, fatigue, myalgia, headache, N&V, agitation, seizures, delirium, followed by neurologic degeneration and death
.

or·o·pha·ryn·ge·al

(ōr'ō-fă-rin'jē-ăl)
Relating to the oropharynx.

or·o·pha·ryn·ge·al

(ōr'ō-fă-rin'jē-ăl)
Relating to oropharynx.
References in periodicals archive ?
Oropharyngeal carriage of Gram-negative bacilli is a matter of interest for healthcare epidemiologists.
(Figure 3 shows results of nondisabled subject swallowing water at 8-10 [degrees]C [cold temperature].) The other parameters of the oropharyngeal swallowing, including the total duration of the SM-EMG, were not significantly changed.
An explanation may be that age-associated changes of increased oropharyngeal transit time and delay in pharyngeal initiation of swallow were being detected (9).
HPV testing by polymerase chain reaction (PCR)-based assays in oropharyngeal tissue has been reported,13 but the lack of a standard protocol for these assays limits their application.
'Previously, it has generally been assumed that oropharyngeal gonorrhoea can only be acquired from an infected penis or anus, not from another man's [throat],' the researchers said.
Overexpression of p16 is a proven prognostic marker in oropharyngeal SCC, because it is a surrogate for transcriptionally active high-risk HPV in tumors.
ORAVI is a novel once-daily mucoadhesive tablet formulation of the antifungal agent miconazole for the treatment of oropharyngeal candidiasis (OPC), a condition that occurs frequently in immunocompromised patients due to HIV, malignant tumours, etc.
M2 EQUITYBITES-January 31, 2019-Sosei Heptares to unveil ORAVI Mucoadhesive tablets in 50mg for treating patients with oropharyngeal candidiasis in Japan
The most common TEAEs reported with LIQ861 in greater than or equal to 4% of PAH patients were cough, headache, throat irritation, diarrhea, dizziness, oropharyngeal pain and chest discomfort.
Ryan Suk, from the University of Texas Health Science Center in Houston, and colleagues used data from nine cancer registries of the Surveillance, Epidemiology, and End Results database to identify 113,272 patients (73,085 female and 40,187 male) patients with HPV-associated cancers (cervical, vaginal, vulvar, oropharyngeal, anal, and penile) diagnosed from 1973 through 2014.
Presence of neck metastasis is a significant prognostic factor in patients with oropharyngeal carcinoma and is associated with a worsening in survival (5).