oromandibular dystonia


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oromandibular dystonia

Neurology A condition that affects the muscles of the jaw, lips, and tongue; the jaw is either open or shut, and may be accompanied by dysphagia and/or dysphonia
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The terms oromandibular dystonia, craniocervical dystonia, or Meige syndrome describe a focal or segmental dystonia whereby repetitive sustained spasms of the masticatory, facial, or lingual muscles result in painful, involuntary, movement of the jaws.
LN hyperechogenicity was observed in 73% (22/30) of patients with cervical dystonia, a prevalence higher than that of patients with blepharospasm (33%, 10/30, P = 0.002) and oromandibular dystonia (40%, 4/10, P = 0.126).
(42.) Hesham Abboud, Ilia Itin, and Hubert Fernandez, "Occupational Oromandibular Dystonia in an Opera Singer Mimicking Spasmodic Dysphonia," Music and Medicine 4, no.
The terms oromandibular dystonia, craniocervical dystonia or Meige syndrome are often used to describe a focal or segmental dystonia whereby repetitive sustained spasms of the masticatory, facial, or lingual muscles result in involuntary, and possibly painful, jaw movements [3,4].
Oromandibular dystonia can occur alone or with other focal or generalized dystonias.
A 74-year-old woman presented with oromandibular dystonia 2 years ago.
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA 20 to 60 80 to 120 Placebo mg/day mg/day (N=168) (N=164) (N=167) Adverse Event Term (%) (%) (%) All EPS events 5 12 20 All EPS events, excluding Akathisia/ 2 5 9 Restlessness Akathisia 2 8 11 Dystonia * 0 0 2 Parkinsonism ** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor Adjunctive Therapy with Lithium or Valproate
Oromandibular dystonia (OMD) is involuntary, repetitive, or twisting spasms of the muscles around the mouth and lower face.
Botulinum toxin A in patients with oromandibular dystonia. Neurology 1999; 53:2102-7.
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA 20 to 60 80 to 120 Placebo mg/day mg/day (N-168) (N=164) (N=167) Adverse Event Term (%) (%) (%) All EPS events 5 12 20 All EPS events, excluding 2 5 9 Akathisia/ Restlessness Akathisia 2 8 11 Dystonia * 0 0 2 Parkinsonism ** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor Adjunctive Therapy with Lithium or Valproate
Patient distribution was as follows: Seven patients had chorea due to HD, 1 had tardive dystonia, 1 had oromandibular dystonia (OMD), 1 had post-ischemic hemidystonia, 1 had hemiballismus, and 1 patient had post-traumatic rubral tremor.
([dagger]) EPS includes the following adverse events: bradykinesia, cogwheel rigidity, drooling, dystonia, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, oculogyric crisis, oromandibular dystonia, parkinsonism, psychomotor retardation, tongue spasm, torticollis, tremor, and trismus.