ornithine decarboxylase


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or·ni·thine de·car·box·yl·ase

an enzyme catalyzing the decarboxylation of l-ornithine to putrescine and CO2; first step in polyamine biosynthesis.
References in periodicals archive ?
Amino acids regulate expression of antizyme-1 to modulate ornithine decarboxylase activity.
Liu, "Ornithine decarboxylase prevents dibenzoylmethane-induced apoptosis through repressing reactive oxygen species generation," Journal of Biochemical and Molecular Toxicology, vol.
Bergeron, "Control of ornithine decarboxylase activity in [alpha]-difluoromethylornithine- resistant L1210 cells by polyamines and synthetic analogues," Journal ofBiological Chemistry, vol.
The level of ODC (ornithine decarboxylase), which converts ornithine to putrescine, is lowered in PMD-resistant cells which accounts for the decreased levels of putrescine in resistant cells [51].
demonstrated that Pso lesions had increased ornithine decarboxylase (ODC) activity in both lesional and non-lesional skin, compared to healthy controls (7).
Our data demonstrated that topical pre-treatment of resveratrol (10 micromol in 200 microl acetone/mouse) resulted in significant inhibition of UV-B exposure-mediated increases in (1) cellular proliferations (Ki-67 immunostaining), (2) protein levels of epidermal cyclooxygenase-2 and ornithine decarboxylase, established markers of tumor promotion, (3) protein and messenger RNA levels of Survivin, and (4) phosphorylation of survivin in the skin of SKH-1 hairless mouse.
DMFO (alpha-difluoromethylornithine, also known as eflornithine) irreversibly inhibits ornithine decarboxylase, an enzyme unregulated in many tumors.
Due to their co-location with ornithine decarboxylase in the cytosol, arginase I can preferentially direct ornithine to the synthesis of polyamines, while arginase II can direct ornithine to the production of proline and glutamate, as both arginase II and ornithine aminotransferase are located in the mitochondria (Figure 5).
speciosa leaves (EHS) was evaluated in a battery of in vitro tests [inhibition of aromatase, NF-[kappa]B and ornithine decarboxylase (ODC), antioxidant response elements (ARE) induction and cell proliferation assays].
API 20E[R] strips also test for the presence of [beta]-galactosidase, arginine dihydrolase, lysine decarboxylase, ornithine decarboxylase, citrate utilization, [H.sub.2]S production, urease, tryptophan deaminase, indole production, acetoin production (Voges - Proskauer), and gelatinase.
All the isolates were examined for the following biochemical characteristics: oxidase production, urease production, Methyl Red and Vogues Proskauer test, indole production, citrate production, arginine dehydrolase, lysine decarboxylase, ornithine decarboxylase, gluconate, malonate, acid production from arabinose, dulcitol, glucose, lactose, maltose, mannitol, raffinose, rhamnose, sorbitol, sucrose, trehalose, and xylose (MacFaddin, 1980).
The enzymatic activity of ornithine decarboxylase (ODC), which is one of the limiting enzymes of PAs biosynthesis, is not well regulated in can cer cells, participating in the transformation of cell phenotype from normal to malignant (Babbar and Gerner, 2003).

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