origin of replication
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or·i·gin of rep·li·ca·tion
a sequence of the bacterial genome required for the initiating of a replicating fork by leading strand synthesis.
Also found in: Acronyms, Encyclopedia, Wikipedia.
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Vignette #1: The tRNA tag hypothesis and the origin of replication
The scientists used this technique to label an area near the origin of replication, a well-kn own site on bacterial chromosomes.
A significant base substitution or insertion in an origin of replication is an example of such a mutation.
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