organophosphorus compound poisoning


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organophosphorus

 [or″gah-no-fos´fah-rus]
a compound containing phosphorus bound to an organic molecule. Some are used as insecticides and others are nerve gases; they are highly toxic acetylcholinesterase inhibitors.
organophosphorus compound poisoning poisoning by excessive exposure to an organophosphorus compound; there are usually neurologic symptoms such as axonopathy and paralysis, and it often ends fatally.

organophosphorus compound poisoning

poisoning, often fatal, by excessive exposure to an organophosphorus compound. There are usually neurological symptoms, such as axonopathy and paralysis.

organophosphorus compound

an organic ester of phosphoric or thiophosphoric acid; such compounds are powerful acetylcholinesterase inhibitors and are used as insecticides and anthelmintics. They are also used industrially as fire-resistant hydraulic fluids, coolants and lubricants and animals may be accidentally exposed to them. All organophosphorus compounds are poisonous, even those used pharmacologically, if given in large enough doses or in particular circumstances.

organophosphorus compound-induced delayed neurotoxicity
paralysis occurring 3 weeks after exposure to organophosphorus compounds, especially industrial organophosphates; the degree of paralysis varies from weakness appearing as knuckling of the fetlocks to complete flaccid paralysis.
industrial organophosphorus compound
see organophosphorus compound (above). Includes aryl-, cresyl-, and tolyl- phosphates used commercially as flame retardants and wood preservatives. Access to the substances or, more commonly, premises contaminated by them may cause poisoning, especially delayed neurotoxicity.
organophosphorus compound insecticide
includes a very wide range of contact insecticides, systemic insecticides for animals and plants; all have significant toxic potential.
organophosphorus compound poisoning
signs of poisoning differ between the species. (1) Cattle show salivation and diarrhea, tremor and stiffness and a pathognomonic constriction of the pupil. (2) Sheep and pigs show predominantly nervous signs. In sheep ataxia, posterior paralysis and spinal cord degeneration are indicators. In pigs nystagmus, tremor, recumbency, posterior paralysis and drowsiness occur. (3) Horses show abdominal pain, diarrhea, ataxia, dyspnea and in foals acute bilateral laryngeal paralysis. (4) Dogs and cats show salivation, tremors and muscle fasciculations, vomiting and diarrhea, constriction of the pupils, ataxia and convulsions.
References in periodicals archive ?
04 Table 7: Requirement of Ventilatory Support in Relation to Severity of Organophosphorus Compound Poisoning Type of Number of Number of P Value Odds Ratio Poisoning Patients Patients with (Ventilation) (n=50) Presented Ventilation Mild 46 (46%) 10 (10%) 0.
3) Organophosphorus compound poisonings are found to be a leading cause of death in agricultural countries globally.
The early causes of death in organophosphorus compound poisonings are chiefly related to ventricular arrhythmias, CNS depression, seizures, or respiratory failure due to excessive bronchial secretions, bronchospasm, pulmonary oedema, aspiration of gastric contents, paralysis of respiratory muscles, or apnoea associated with depression of the medullary respiratory center.
In the studied group of 110 patients with organophosphorus compound poisoning brought to Chengalpattu Medical College Hospital, 62.
Association of Severe Organophosphorus Compound Poisoning by Peradeniya Organophosphorus Poisoning Scale with CPK, SGOT, and SGPT
The present study found that the initial serum CPK level is comparable for BChE level and can be used as an alternative biomarker in diagnosis of acute organophosphorus compound poisoning provided that exclusion of any other diseases or conditions that may cause rise in CPK levels, these results were statistically significant (p <0.
The present work highlighted the importance of measurement of serum CPK levels as it might be helpful in predicting as well as assessing the prognosis of patients with acute organophosphorus compound poisoning.
RESULTS: There are 298 cases of organophosphorus compound poisoning which were admitted to medical wards in Basaveshwar Teaching and General Hospital during study period.
DISCUSSION: In this study 100 cases organophosphorus compound poisoning were studied clinically and following observation were made:
derangements were found statistically insignificant in present study and are not helpful in assessing prognosis in organophosphorus compound poisoning.
Estimation of electrocardiographic changes will be useful parameter in assessing prognosis of organophosphorus compound poisoning patients.

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